Literature DB >> 17997038

Smoking upregulates alpha4beta2* nicotinic acetylcholine receptors in the human brain.

Ullrich Wüllner1, Daniela Gündisch, Hans Herzog, Martina Minnerop, Alexis Joe, Marc Warnecke, Frank Jessen, Christian Schütz, Michael Reinhardt, Wolfgang Eschner, Thomas Klockgether, Joern Schmaljohann.   

Abstract

The role of the alpha4beta2* nicotinic acetylcholine receptors (nAChR) in tobacco addiction in humans is largely unresolved. We visualized brain alpha4beta2* nicotinic acetylcholine receptors of smokers and non-smokers with positron emission tomography using 2-[(18)F]fluoro-3-(2(S)azetidinylmethoxy)pyridine, commonly known as 2-[(18)F]F-A-85380. The total brain distribution volume of 2-[(18)F]F-A-85380 was significantly increased in smokers. Statistical parametric mapping revealed that the most prominent regional differences of distribution volumes (DV) were found in cerebellum and brainstem with an increased uptake in smokers. The up-regulation of alpha4beta2* nAChR upon chronic nicotine exposure via tobacco smoking incorporates subcortical brain regions which may play an important role in nicotine addiction.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17997038     DOI： 10.1016/j.neulet.2007.10.011

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  26 in total

1.  Positron emission tomography experience with 2-[¹⁸F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[¹⁸F]FA) in the living human brain of smokers with paranoid schizophrenia.

Authors:  James Robert Brašić; Nicola Cascella; Anil Kumar; Yun Zhou; John Hilton; Vanessa Raymont; Andrew Crabb; Maria Rita Guevara; Andrew G Horti; Dean Foster Wong
Journal:  Synapse       Date:  2011-12-29       Impact factor: 2.562

2.  Nicotinic acetylcholine receptor expression on B-lymphoblasts of healthy versus schizophrenic subjects stratified for smoking: [3H]-nicotine binding is decreased in schizophrenia and correlates with negative symptoms.

Authors:  Christian Luckhaus; Uwe Henning; Stefano Ferrea; Francesco Musso; Arian Mobascher; Georg Winterer
Journal:  J Neural Transm (Vienna)       Date:  2011-12-11       Impact factor: 3.575

3.  Quantitative Molecular Imaging of Neuronal Nicotinic Acetylcholine Receptors in the Human Brain with A-85380 Radiotracers.

Authors:  Shahrdad Lotfipour; Mark Mandelkern; Arthur L Brody
Journal:  Curr Med Imaging Rev       Date:  2011-05-01

4.  Feasibility of [18F]-2-Fluoro-A85380-PET imaging of human vascular nicotinic acetylcholine receptors in vivo.

Authors:  Jan Bucerius; Christoph Manka; Jörn Schmaljohann; Venkatesh Mani; Daniela Gündisch; James H F Rudd; Rolf Bippus; Felix M Mottaghy; Ullrich Wüllner; Zahi A Fayad; Hans-Jürgen Biersack
Journal:  JACC Cardiovasc Imaging       Date:  2012-05

Review 5.  Inside-out neuropharmacology of nicotinic drugs.

Authors:  Brandon J Henderson; Henry A Lester
Journal:  Neuropharmacology       Date:  2015-02-04       Impact factor: 5.250

6.  Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment: a randomized trial.

Authors:  Arthur L Brody; Alexey G Mukhin; Michael S Mamoun; Trinh Luu; Meaghan Neary; Lidia Liang; Jennifer Shieh; Catherine A Sugar; Jed E Rose; Mark A Mandelkern
Journal:  JAMA Psychiatry       Date:  2014-07-01       Impact factor: 21.596

7.  Impact of short access nicotine self-administration on expression of α4β2* nicotinic acetylcholine receptors in non-human primates.

Authors:  Bernard Le Foll; Svetlana I Chefer; Alane S Kimes; Elliot A Stein; Steven R Goldberg; Alexey G Mukhin
Journal:  Psychopharmacology (Berl)       Date:  2016-02-25       Impact factor: 4.530

8.  Correlation between pulmonary function and brain volume in healthy elderly subjects.

Authors:  Yasuyuki Taki; Shigeo Kinomura; Satoru Ebihara; Benjamin Thyreau; Kazunori Sato; Ryoi Goto; Masako Kakizaki; Ichiro Tsuji; Ryuta Kawashima; Hiroshi Fukuda
Journal:  Neuroradiology       Date:  2013-02-26       Impact factor: 2.804

9.  Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density.

Authors:  Arthur L Brody; Alexey G Mukhin; Michael S Mamoun; Maggie Kozman; Jonathan Phuong; Meaghan Neary; Trinh Luu; Mark A Mandelkern
Journal:  Neuropsychopharmacology       Date:  2013-02-21       Impact factor: 7.853

10.  Single photon emission computed tomography experience with (S)-5-[(123)I]iodo-3-(2-azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers.

Authors:  James Robert Brasić; Yun Zhou; John L Musachio; John Hilton; Hong Fan; Andrew Crabb; Christopher J Endres; Melvin J Reinhardt; Ahmet S Dogan; Mohab Alexander; Olivier Rousset; Marika A Maris; Jeffrey Galecki; Ayon Nandi; Dean F Wong
Journal:  Synapse       Date:  2009-04       Impact factor: 2.562
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.