INTRODUCTION: We performed a pooled analysis of randomised clinical trials (RCT) on HPV vaccine efficacy in preventing cervical persistent infection. METHODS: We carried out a bibliographic search on electronic databases and we selected RCT to perform the meta-analyses. RESULTS: We selected five studies. The first meta-analysis, including all studies, showed an important reduction of the risk of infection from HPV 16 in vaccinated cohort [RR 0.10 (95% CI: 0.07-0.15)]. The second and third meta-analyses, including only studies on bivalent and tetravalent vaccines, showed a RR of 0.13 (95% CI: 0.09-0.20) for HPV 16 infections and a RR of 0.22 (95% CI: 0.13-0.38) for HPV 18 ones. DISCUSSION: HPV vaccine efficacy in preventing persistent infection is high but there is the need for further studies on the duration of immunization and long-term vaccine efficacy.
INTRODUCTION: We performed a pooled analysis of randomised clinical trials (RCT) on HPV vaccine efficacy in preventing cervical persistent infection. METHODS: We carried out a bibliographic search on electronic databases and we selected RCT to perform the meta-analyses. RESULTS: We selected five studies. The first meta-analysis, including all studies, showed an important reduction of the risk of infection from HPV 16 in vaccinated cohort [RR 0.10 (95% CI: 0.07-0.15)]. The second and third meta-analyses, including only studies on bivalent and tetravalent vaccines, showed a RR of 0.13 (95% CI: 0.09-0.20) for HPV 16infections and a RR of 0.22 (95% CI: 0.13-0.38) for HPV 18 ones. DISCUSSION: HPV vaccine efficacy in preventing persistent infection is high but there is the need for further studies on the duration of immunization and long-term vaccine efficacy.
Authors: Orkun Çetin; Fatma Ferda Verit; Seda Keskin; Ali Galip Zebitay; Ayşegül Deregözü; Taner Usta; Oğuz Yücel Journal: Turk Pediatri Ars Date: 2014-06-01
Authors: Ali Rowhani-Rahbar; Constance Mao; James P Hughes; Frances B Alvarez; Janine T Bryan; Stephen E Hawes; Noel S Weiss; Laura A Koutsky Journal: Vaccine Date: 2009-07-30 Impact factor: 3.641
Authors: Yvonne Deleré; Ole Wichmann; Stefanie J Klug; Marianne van der Sande; Martin Terhardt; Fred Zepp; Thomas Harder Journal: Dtsch Arztebl Int Date: 2014-09-01 Impact factor: 5.594