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Literature DB >> 17996986

The complex roles of neurosteroids in depression and anxiety disorders.

Patrizia Longone¹, Rainer Rupprecht, Gaia A Manieri, Giorgio Bernardi, Elena Romeo, Augusto Pasini.

Abstract

The role of neurosteroids in neuropsychiatric disorders has been thoroughly investigated in many research studies that have stressed their significant pathophysiological function in neuropsychiatry. In this review, we will focus mainly on the steroids active on the GABA(A) receptors studied in anxiety and depression. The aim is to discuss the controversial results reported in research on anxiety and depressive disorders. We suggest the combined use of biological parameters linked to psychopathological dimensions to make more homogeneous diagnoses and to develop more precise therapies for the treatment of depression and anxiety disorders. We discuss the role of neurosteroids in the pathophysiology and therapy of anxiety and depression. Finally, we consider the possibility of using quantification of mRNA expression of steroidogenic enzymes from peripheral sources in neuropsychiatry.

Entities: Chemical Disease

Mesh：

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Year: 2007 PMID： 17996986 DOI： 10.1016/j.neuint.2007.10.001

Source DB: PubMed Journal: Neurochem Int ISSN： 0197-0186 Impact factor: 3.921

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Cited

19 in total

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2. 5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann's area 9 (BA9) of depressed patients.

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3. The antidepressant-like effect of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane involves a regulation of β-type estrogen receptors.

Authors: Julie Espallergues; Jamal Temsamani; Claude Laruelle; Alexandre Urani; Tangui Maurice
Journal: Psychopharmacology (Berl) Date: 2010-10-28 Impact factor: 4.530

4. Association of the GABRD gene and childhood-onset mood disorders.

Authors: Y Feng; K Kapornai; E Kiss; Z Tamás; L Mayer; I Baji; G Daróczi; I Benák; V O Kothencné; E Dombovári; E Kaczvinszk; M Besnyo; J Gádoros; J Székely; M Kovacs; A Vetró; J L Kennedy; C L Barr
Journal: Genes Brain Behav Date: 2010-06-18 Impact factor: 3.449

5. Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones.

Authors: Adam R Brown; Murray B Herd; Delia Belelli; Jeremy J Lambert
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6. A mutant residue in the third transmembrane region of the GABA(A) alpha1 subunit causes increased agonistic neurosteroid responses.

Authors: Daniel B Williams
Journal: Neurochem Int Date: 2011-03-21 Impact factor: 3.921

The complex roles of neurosteroids in depression and anxiety disorders.

1. Prevalence, incidence, and persistence of psychiatric and substance use disorders among mothers living with HIV.

2. 5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann's area 9 (BA9) of depressed patients.

3. The antidepressant-like effect of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane involves a regulation of β-type estrogen receptors.

4. Association of the GABRD gene and childhood-onset mood disorders.

5. Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones.

6. A mutant residue in the third transmembrane region of the GABA(A) alpha1 subunit causes increased agonistic neurosteroid responses.

7. GABA(A)R plasticity during pregnancy: relevance to postpartum depression.

8. Steroid hormone fluctuations and GABA(A)R plasticity.

Review 9. Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice.

Review 10. A reproductive subtype of depression: conceptualizing models and moving toward etiology.