| Literature DB >> 17994687 |
Jinshan Wang1, Peter Gutierrez, Nathan Edwards, Catherine Fenselau.
Abstract
Forward and reverse (18)O labeling are integrated with solution isoelectric focusing and capillary LC-tandem mass spectrometry to evaluate a new strategy for quantitative proteomics and to study abundance changes in mitochondrial proteins associated with drug resistance in MCF-7 human cancer cells. Galectin-3 binding protein, which is involved in apoptosis, was detected only in the resistant cell line, as a result of reverse labeling. Among 278 proteins identified, 12 were detected with abundances altered at least 2-fold.Entities:
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Year: 2007 PMID： 17994687 PMCID： PMC2562304 DOI： 10.1021/pr070401e
Source DB: PubMed Journal: J Proteome Res ISSN： 1535-3893 Impact factor: 4.466