Literature DB >> 17994605

gamma-Substituted bis(pivaloyloxymethyl)ester analogues of fosmidomycin and FR900098.

Thomas Kurz1, Christoph Behrendt, Miriam Pein, Uwe Kaula, Bärbel Bergmann, Rolf D Walter.   

Abstract

The synthesis and in-vitro antimalarial activity of gamma-substituted bis(pivaloyloxymethyl)ester analogues of the drug candidate fosmidomycin have been investigated. In contrast to the high antimalarial activity of alpha-aryl substituted fosmidomycin analogues like alpha-phenylfosmidomycin, gamma-substituted derivatives display only weak to moderate activity against the chloroquine-sensitive strain 3D7 of Plasmodium falciparum.

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Year:  2007        PMID： 17994605     DOI： 10.1002/ardp.200700107

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  8 in total

Review 1.  Biochemistry of the non-mevalonate isoprenoid pathway.

Authors:  Tobias Gräwert; Michael Groll; Felix Rohdich; Adelbert Bacher; Wolfgang Eisenreich
Journal:  Cell Mol Life Sci       Date:  2011-07-09       Impact factor: 9.261

2.  Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr).

Authors:  Christopher M Armstrong; David J Meyers; Leah S Imlay; Caren Freel Meyers; Audrey R Odom
Journal:  Antimicrob Agents Chemother       Date:  2015-06-29       Impact factor: 5.191

3.  Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs.

Authors:  Eugene Uh; Emily R Jackson; Géraldine San Jose; Marcus Maddox; Robin E Lee; Richard E Lee; Helena I Boshoff; Cynthia S Dowd
Journal:  Bioorg Med Chem Lett       Date:  2011-10-05       Impact factor: 2.823

4.  Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene.

Authors:  Audrey R Odom; Wesley C Van Voorhis
Journal:  Mol Biochem Parasitol       Date:  2009-12-16       Impact factor: 1.759

5.  Design of Potential Bisubstrate Inhibitors against Mycobacterium tuberculosis (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)-Evidence of a Novel Binding Mode.

Authors:  Géraldine San Jose; Emily R Jackson; Eugene Uh; Chinchu Johny; Amanda Haymond; Lindsay Lundberg; Chelsea Pinkham; Kylene Kehn-Hall; Helena I Boshoff; Robin D Couch; Cynthia S Dowd
Journal:  Medchemcomm       Date:  2013-07-01       Impact factor: 3.597

6.  Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines.

Authors:  Vida Zohrabi-Kalantari; Philipp Heidler; Marcel Kaiser; Reto Brun; Christoph Kamper; Andreas Link
Journal:  Mol Divers       Date:  2009-06-26       Impact factor: 2.943

7.  Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy.

Authors:  Elizabeth S McKenney; Michelle Sargent; Hameed Khan; Eugene Uh; Emily R Jackson; Géraldine San Jose; Robin D Couch; Cynthia S Dowd; Monique L van Hoek
Journal:  PLoS One       Date:  2012-10-15       Impact factor: 3.240

8.  In silico identification of promiscuous scaffolds as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria.

Authors:  Abdul Wadood; Mehreen Ghufran; Syed Fahad Hassan; Huma Khan; Syed Sikandar Azam; Umer Rashid
Journal:  Pharm Biol       Date:  2016-09-21       Impact factor: 3.503
  8 in total

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