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Literature DB >> 17994392

Novel diterpenes with cytotoxic, anti-malarial and anti-tuberculosis activities from a brown alga Dictyota sp.

Abstract

Two new diterpenes, (1E,2R*,3R*,4S*,6E,18S*)-4,18-dihydroxydictyolactone (1) and 8alpha,11-dihydroxypachydictyol A (2), together with fucoxanthin (3) and a known diterpene 4alpha-hydroxycrenulatane (4) were isolated from the methanol extract of the brown alga Dictyota sp. collected from Bangsaen Beach, Thailand. Their structures were determined by spectroscopic data. The relative stereochemistry of 1 was established by NOE difference and NOESY experiments. Compound 1 showed weak anti-tuberculosis activity while 2 displayed strong cytotoxicity against the NCI-H187 cell line, and potent anti-malarial activity. In addition, 3 was active against HSV-1 and malarial parasites.

Entities: Chemical Disease Species

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Substances：

Year: 2007 PMID： 17994392 DOI： 10.1080/10286020701189203

Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569

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Cited

6 in total

1. Anticoagulation and antiplatelet effects of a dolastane diterpene isolated from the marine brown alga Canistrocarpus cervicornis.

Authors: Laura de Andrade Moura; Everson Miguel Bianco; Renato Crespo Pereira; Valéria Laneuville Teixeira; André Lopes Fuly
Journal: J Thromb Thrombolysis Date: 2011-02 Impact factor: 2.300

2. Macroalgae of Izmir Gulf: Dictyotaceae exhibit high in vitro anti-cancer activity independent from their antioxidant capabilities.

Authors: Fatma Gül Çelenk; Ali Burak Özkaya; Atakan Sukatar
Journal: Cytotechnology Date: 2016-07-04 Impact factor: 2.058

3. Update of spectroscopic data for 4-hydroxydictyolactone and dictyol E isolated from a Halimeda stuposa - Dictyota sp. assemblage.

Authors: Simon P B Ovenden; Jonathan L Nielson; Catherine H Liptrot; Richard H Willis; Dianne M Tapiolas; Anthony D Wright; Cherie A Motti
Journal: Molecules Date: 2012-03-08 Impact factor: 4.411

Novel diterpenes with cytotoxic, anti-malarial and anti-tuberculosis activities from a brown alga Dictyota sp.

1. Anticoagulation and antiplatelet effects of a dolastane diterpene isolated from the marine brown alga Canistrocarpus cervicornis.

2. Macroalgae of Izmir Gulf: Dictyotaceae exhibit high in vitro anti-cancer activity independent from their antioxidant capabilities.

3. Update of spectroscopic data for 4-hydroxydictyolactone and dictyol E isolated from a Halimeda stuposa - Dictyota sp. assemblage.

4. Biological importance of marine algae.

Review 5. Diterpenes from the Marine Algae of the Genus Dictyota.

Review 6. What Do We Know about Antimicrobial Activity of Astaxanthin and Fucoxanthin?