| Literature DB >> 17994369 |
Jay W Tichelaar1, Scott C Wesselkamper, Supurna Chowdhury, Hulian Yin, Pierre-Yves Berclaz, Maureen A Sartor, George D Leikauf, Jeffrey A Whitsett.
Abstract
Fibroblast growth factor-7 (FGF7) is a lung epithelial cell mitogen that is cytoprotective during injury. Transgenic mice that conditionally expressed FGF7 were used to dissect the mechanisms of FGF7 protection during lung injury. FGF7 improved survival when induced 3 days prior to acute lung injury. In contrast, FGF7 caused pulmonary inflammation and lung injury after 7 days or longer. Gene expression analysis of mouse lung mRNA identified mRNAs that contribute to the protective effects of FGF7. FGF7 improved survival during acute lung injury in adult mouse lung after short-term expression, but paradoxically induced inflammation and injury after persistent expression.Entities:
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Year: 2007 PMID： 17994369 DOI： 10.1080/01902140701703226
Source DB: PubMed Journal: Exp Lung Res ISSN： 0190-2148 Impact factor: 2.459