Literature DB >> 17993289

Different expression of MAGE-A-antigens in foetal and adult keratinocyte cell lines.

Urs D A Müller-Richter1, Albert Dowejko, Weiqi Zhou, Torsten E Reichert, Oliver Driemel.   

Abstract

MAGE-A-antigens are an immunologic marker for many cancers. The goal of this study was to compare the expression profiles of MAGE-A2, -A3, -A4, -A6 and -A10 in foetal and adult keratinocytes with an oral squamous cell carcinoma (OSCC) cell line. Expression of MAGE-A2, -A3, -A4, -A6 and -A10-antigens were detected with PCR in foetal and adult keratinocyte cell lines and in an OSCC cell line (pT4N1M0). Quantitative expression of the single MAGE-A-antigens was measured with rtq-PCR. The results were compared to the reference value of the adult keratinocyte cell line. MAGE-A-antigens were detected in all cell lines. Expression profiles of adult and foetal keratinocyte cell lines differed significantly. Expression profiles of foetal and carcinoma cell lines differed significantly also. MAGE-A-antigens were detected in foetal keratinocyte cell line and oral squamous cell carcinoma cell line but differ in their expression profiles. Up to now MAGE-A-antigens were not detected in foetal keratinocytes. Their role is still unknown.

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Year:  2007        PMID： 17993289     DOI： 10.1016/j.oraloncology.2007.08.007

Source DB:  PubMed          Journal:  Oral Oncol        ISSN： 1368-8375            Impact factor:   5.337


  8 in total

1.  MAGE-A antigens in lesions of the oral mucosa.

Authors:  Eva Krauss; Stephan Rauthe; Stefan Gattenlöhner; Tobias Reuther; Michael Kochel; Ulrike Kriegebaum; Alexander C Kübler; Urs D A Müller-Richter
Journal:  Clin Oral Investig       Date:  2010-02-20       Impact factor: 3.573

2.  Correlation of MAGE-A tumor antigens and the efficacy of various chemotherapeutic agents in head and neck carcinoma cells.

Authors:  S Hartmann; U Kriegebaum; N Küchler; R C Brands; C Linz; A C Kübler; U D A Müller-Richter
Journal:  Clin Oral Investig       Date:  2013-02-21       Impact factor: 3.573

3.  MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation.

Authors:  Till J Meyer; Stefan Hartmann; Gisela Wohlleben; Muna Brisam; Axel Seher; Alexander C Kübler; Bülent Polat; Urs D A Müller-Richter
Journal:  Mol Clin Oncol       Date:  2018-01-19

4.  MAGE-A11 expression contributes to cisplatin resistance in head and neck cancer.

Authors:  Stefan Hartmann; Leonie Zwick; Mario J J Scheurer; Andreas R Fuchs; Roman C Brands; Axel Seher; Hartmut Böhm; Alexander C Kübler; Urs D A Müller-Richter
Journal:  Clin Oral Investig       Date:  2017-10-15       Impact factor: 3.573

5.  Melanoma-associated antigen expression and the efficacy of tyrosine kinase inhibitors in head and neck cancer.

Authors:  Stefan Hartmann; Roman C Brands; Nora Küchler; Andreas Fuchs; Christian Linz; Alexander C Kübler; Urs D A Müller-Richter
Journal:  Oncol Lett       Date:  2015-06-09       Impact factor: 2.967

6.  Impact of MAGE-A antigens on taxane response in oral squamous cell carcinoma.

Authors:  Urs D A Müller-Richter; Albert Dowejko; Oliver Driemel; Tobias Reuther; Torsten E Reichert; Alexander C Kübler
Journal:  Oncol Lett       Date:  2010-01-01       Impact factor: 2.967

7.  MAGE-A antigens in patients with primary oral squamous cell carcinoma.

Authors:  Urs D A Müller-Richter; Albert Dowejko; Silvia Peters; Stephan Rauthe; Tobias Reuther; Stefan Gattenlöhner; Torsten E Reichert; Oliver Driemel; Alexander C Kübler
Journal:  Clin Oral Investig       Date:  2009-06-02       Impact factor: 3.573

8.  Analysis of expression profiles of MAGE-A antigens in oral squamous cell carcinoma cell lines.

Authors:  Urs D A Müller-Richter; Albert Dowejko; Tobias Reuther; Johannes Kleinheinz; Torsten E Reichert; Oliver Driemel
Journal:  Head Face Med       Date:  2009-04-09       Impact factor: 2.151
  8 in total

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