OBJECTIVE: This study aimed at identifying predictive variables for in-hospital mortality, calculating the probability of death and creating a risk index for death by infective endocarditis by comparing two methods using a Receiver Operating Characteristic (ROC) curve. METHODS: A retrospective study was conducted of 186 consecutive cases of confirmed infective endocarditis divided into two groups: discharged (137) and in-hospital death (49). Based on the odds ratios obtained by multivariate analysis, the probability of death was calculated and a mortality risk index created. RESULTS: Factors predictive of higher mortality (multivariate analysis) and the risk index, with their respective weights were: age >or= 40 years (OR = 4.16; 95%CI [1.63-10.80] - 4 points), class IV heart failure or cardiovascular shock (OR = 4.93; 95%CI [1.86-13.05] - 5 points), uncontrolled sepsis (OR = 5.97; 95%CI [1.95-18.35] - 6 points), conduction disorder (OR = 5.07; 95%CI [1.67-15.35] - 5 points), arrhythmia (OR = 8.17; 95%CI [2.60-25.71] - 8 points), valve with extensive damage or abscess or prosthesis (OR = 4.77; 95%CI [1.44-15.76] - 5 points) and large and mobile vegetation (OR = 4.36; 95%CI [1.55-12.90] - 4 points). Patients with scores between 0 and 10 had a mortality of 5.26% and scores over 20 of 78.9%. CONCLUSIONS: The higher the score, the higher the mortality rate. The mortality risk index may be used to estimate mortality in Infective Endocarditis.
OBJECTIVE: This study aimed at identifying predictive variables for in-hospital mortality, calculating the probability of death and creating a risk index for death by infective endocarditis by comparing two methods using a Receiver Operating Characteristic (ROC) curve. METHODS: A retrospective study was conducted of 186 consecutive cases of confirmed infective endocarditis divided into two groups: discharged (137) and in-hospital death (49). Based on the odds ratios obtained by multivariate analysis, the probability of death was calculated and a mortality risk index created. RESULTS: Factors predictive of higher mortality (multivariate analysis) and the risk index, with their respective weights were: age >or= 40 years (OR = 4.16; 95%CI [1.63-10.80] - 4 points), class IV heart failure or cardiovascular shock (OR = 4.93; 95%CI [1.86-13.05] - 5 points), uncontrolled sepsis (OR = 5.97; 95%CI [1.95-18.35] - 6 points), conduction disorder (OR = 5.07; 95%CI [1.67-15.35] - 5 points), arrhythmia (OR = 8.17; 95%CI [2.60-25.71] - 8 points), valve with extensive damage or abscess or prosthesis (OR = 4.77; 95%CI [1.44-15.76] - 5 points) and large and mobile vegetation (OR = 4.36; 95%CI [1.55-12.90] - 4 points). Patients with scores between 0 and 10 had a mortality of 5.26% and scores over 20 of 78.9%. CONCLUSIONS: The higher the score, the higher the mortality rate. The mortality risk index may be used to estimate mortality in Infective Endocarditis.
Authors: Marisa De Feo; Maurizio Cotrufo; Antonio Carozza; Luca S De Santo; Francesco Amendolara; Salvatore Giordano; Ester E Della Ratta; Gianantonio Nappi; Alessandro Della Corte Journal: ScientificWorldJournal Date: 2012-03-12
Authors: Antonio Salsano; Daniele Roberto Giacobbe; Filippo Del Puente; Roberto Natali; Ambra Miette; Sara Moscatelli; Giacomo Perocchio; Flavio Scarano; Italo Porto; Giovanni Mariscalco; Matteo Bassetti; Francesco Santini Journal: Open Med (Wars) Date: 2020-06-20