Literature DB >> 17992293

Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs.

Olivia R Allen1, Andrew L Gott, John A Hartley, Janet M Hartley, Richard J Knox, Patrick C McGowan.   

Abstract

A number of new ionic titanocene compounds have been isolated and characterised, which exhibit excellent cytotoxicity against different human tumour cell lines including a defined cisplatin resistant cell line. A range of biological assays have been carried out to determine levels of cytotoxicity and levels of DNA interstrand crosslinking.

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Year:  2007        PMID： 17992293     DOI： 10.1039/b708283p

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  6 in total

Review 1.  A ubiquitous metal, difficult to track: towards an understanding of the regulation of titanium(iv) in humans.

Authors:  Sergio A Loza-Rosas; Manoj Saxena; Yamixa Delgado; Kavita Gaur; Mallesh Pandrala; Arthur D Tinoco
Journal:  Metallomics       Date:  2017-04-19       Impact factor: 4.526

2.  Expanding the Therapeutic Potential of the Iron Chelator Deferasirox in the Development of Aqueous Stable Ti(IV) Anticancer Complexes.

Authors:  Sergio A Loza-Rosas; Alexandra M Vázquez-Salgado; Kennett I Rivero; Lenny J Negrón; Yamixa Delgado; Josué A Benjamín-Rivera; Angel L Vázquez-Maldonado; Timothy B Parks; Charlene Munet-Colón; Arthur D Tinoco
Journal:  Inorg Chem       Date:  2017-06-23       Impact factor: 5.165

Review 3.  Scope of organometallic compounds based on transition metal-arene systems as anticancer agents: starting from the classical paradigm to targeting multiple strategies.

Authors:  Mehvash Zaki; Suboot Hairat; Elham S Aazam
Journal:  RSC Adv       Date:  2019-01-24       Impact factor: 4.036

4.  Water-soluble molybdenocene complexes with both proliferative and antiproliferative effects on cancer cell lines and their binding interactions with human serum albumin.

Authors:  Idainés Feliciano; Jaime Matta; Enrique Meléndez
Journal:  J Biol Inorg Chem       Date:  2009-06-18       Impact factor: 3.358

5.  On the discovery, biological effects, and use of Cisplatin and metallocenes in anticancer chemotherapy.

Authors:  Santiago Gómez-Ruiz; Danijela Maksimović-Ivanić; Sanja Mijatović; Goran N Kaluđerović
Journal:  Bioinorg Chem Appl       Date:  2012-07-12       Impact factor: 7.778

6.  Synthesis and biological evaluation of achiral indole-substituted titanocene dichloride derivatives.

Authors:  Anthony Deally; Frauke Hackenberg; Grainne Lally; Matthias Tacke
Journal:  Int J Med Chem       Date:  2012-06-12
  6 in total

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