Literature DB >> 17991750

High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).

Huey-Sheng Shieh1, Karl J Mathis, Jennifer M Williams, Robert L Hills, Joe F Wiese, Timothy E Benson, James R Kiefer, Margaret H Marino, Jeffery N Carroll, Joseph W Leone, Anne-Marie Malfait, Elizabeth C Arner, Micky D Tortorella, Alfredo Tomasselli.   

Abstract

Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis.

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Year:  2007        PMID： 17991750     DOI： 10.1074/jbc.M705879200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  25 in total

1.  Using fluorogenic peptide substrates to assay matrix metalloproteinases.

Authors:  G B Fields
Journal:  Methods Mol Biol       Date:  2001

2.  Structure of human ADAM-8 catalytic domain complexed with batimastat.

Authors:  Troii Hall; Huey Sheng Shieh; Jacqueline E Day; Nicole Caspers; Jill E Chrencik; Jennifer M Williams; Lyle E Pegg; Adele M Pauley; Andrea F Moon; Joseph M Krahn; David H Fischer; James R Kiefer; Alfredo G Tomasselli; Marc D Zack
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-05-22

3.  Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors.

Authors:  Micky D Tortorella; Alfredo G Tomasselli; Karl J Mathis; Mark E Schnute; Scott S Woodard; Grace Munie; Jennifer M Williams; Nicole Caspers; Arthur J Wittwer; Anne-Marie Malfait; Huey-Sheng Shieh
Journal:  J Biol Chem       Date:  2009-07-08       Impact factor: 5.157

4.  Structural characterization of the ectodomain of a disintegrin and metalloproteinase-22 (ADAM22), a neural adhesion receptor instead of metalloproteinase: insights on ADAM function.

Authors:  Heli Liu; Ann H R Shim; Xiaolin He
Journal:  J Biol Chem       Date:  2009-08-18       Impact factor: 5.157

5.  ADAMTS13 and von Willebrand factor interactions.

Authors:  Catherine B Zander; Wenjing Cao; X Long Zheng
Journal:  Curr Opin Hematol       Date:  2015-09       Impact factor: 3.284

6.  Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13.

Authors:  L Deforche; E Roose; A Vandenbulcke; N Vandeputte; H B Feys; T A Springer; L Z Mi; J Muia; J E Sadler; K Soejima; H Rottensteiner; H Deckmyn; S F De Meyer; K Vanhoorelbeke
Journal:  J Thromb Haemost       Date:  2015-10-20       Impact factor: 5.824

7.  Structure analysis reveals the flexibility of the ADAMTS-5 active site.

Authors:  Huey-Sheng Shieh; Alfredo G Tomasselli; Karl J Mathis; Mark E Schnute; Scott S Woodard; Nicole Caspers; Jennifer M Williams; James R Kiefer; Grace Munie; Arthur Wittwer; Anne-Marie Malfait; Micky D Tortorella
Journal:  Protein Sci       Date:  2011-04       Impact factor: 6.725

Review 8.  Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and function.

Authors:  Dirk Hubmacher; Suneel S Apte
Journal:  Cell Mol Life Sci       Date:  2011-08-20       Impact factor: 9.261

Review 9.  Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.

Authors:  Suneel S Apte
Journal:  Biochem J       Date:  2016-01-01       Impact factor: 3.857

10.  Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13.

Authors:  Masashi Akiyama; Soichi Takeda; Koichi Kokame; Junichi Takagi; Toshiyuki Miyata
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-06-30
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