| Literature DB >> 17991425 |
Makoto Daimon1, Hidenori Sato, Toshihide Oizumi, Sayumi Toriyama, Takafumi Saito, Shigeru Karasawa, Yumi Jimbu, Kiriko Wada, Wataru Kameda, Shinji Susa, Hiroshi Yamaguchi, Mitsuru Emi, Masaaki Muramatsu, Isao Kubota, Sumio Kawata, Takeo Kato.
Abstract
The associations of five SNPs (SNPs1-5: A-5468G, A-3333G, C-1794T, C437T and T9148C) of the class II phosphoinositide 3-kinase gamma-subunit (PIK3C2G) gene with type 2 diabetes were examined using a population of the Takahata Study (n (M/W): 2930 (1328/1602); age: 63.3+/-10.2 years), a Japanese community-based study. Quantitative association study of the SNPs with HbA1c levels showed significant association for SNPs 2 and 4 (p=0.018 and 0.004, respectively). A case-control association study of SNP 4 with diabetes by multiple logistic regression analysis showed a significant association of the genotype TT of the SNP with an odds ratio of 2.21 (p=0.001) independently of age, gender and BMI. In the NGT subjects, serum fasting insulin levels in the at-risk genotype group of SNP 4 were significantly lower than those in the others (TT, TC, and CC, 4.9+/-2.6, 5.4+/-3.0, and 5.6+/-3.4muU/ml, respectively; p=0.029).Entities:
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Year: 2007 PMID： 17991425 DOI： 10.1016/j.bbrc.2007.10.180
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575