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Literature DB >> 17990107

Increased expression of long pentraxin PTX3 in inflammatory bowel diseases.

Shingo Kato¹, Mitsuko Ochiai, Tomoya Sakurada, Shino Ohno, Kyoko Miyamoto, Mina Sagara, Masataka Ito, Kyoko Takeuchi, Junko Imaki, Kazuro Itoh, Koji Yakabi.

Abstract

The aims of this study were to investigate the expression of pentraxin-3 in inflamed gastrointestinal tissue in patients with inflammatory bowel diseases and to elucidate the usefulness of plasma pentraxin-3 level as an inflammation marker in patients with inflammatory bowel diseases. Pentraxin-3 immunoreactivity was found in infiltrating neutrophils and vessels in the inflamed gut. Plasma pentraxin-3 concentration in patients with active inflammatory bowel diseases was significantly higher than that of normal subjects and patients with inactive inflammatory bowel diseases. Significant positive correlations of clinical disease activity with plasma pentraxin-3 concentration and serum CRP concentration were found in patients with inflammatory bowel diseases. Pentraxin-3 is directly produced from the inflamed gut in inflammatory bowel diseases. In conclusion, plasma pentraxin-3 concentration is a useful marker for understanding the disease activity in patients with inflammatory bowel diseases.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17990107 DOI： 10.1007/s10620-007-0075-z

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

43 in total

1. PTX3, A prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans.

Authors: G Peri; M Introna; D Corradi; G Iacuitti; S Signorini; F Avanzini; F Pizzetti; A P Maggioni; T Moccetti; M Metra; L D Cas; P Ghezzi; J D Sipe; G Re; G Olivetti; A Mantovani; R Latini
Journal: Circulation Date: 2000-08-08 Impact factor: 29.690

2. Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component.

Authors: B Bottazzi; V Vouret-Craviari; A Bastone; L De Gioia; C Matteucci; G Peri; F Spreafico; M Pausa; C D'Ettorre; E Gianazza; A Tagliabue; M Salmona; F Tedesco; M Introna; A Mantovani
Journal: J Biol Chem Date: 1997-12-26 Impact factor: 5.157

Review 3. The long pentraxin PTX3 in vascular pathology.

Authors: Alberto Mantovani; Cecilia Garlanda; Barbara Bottazzi; Giuseppe Peri; Andrea Doni; Yeny Martinez de la Torre; Roberto Latini
Journal: Vascul Pharmacol Date: 2006-08-23 Impact factor: 5.773

4. Increased mortality and inflammation in tumor necrosis factor-stimulated gene-14 transgenic mice after ischemia and reperfusion injury.

Authors: Danielle G Souza; Adriana C Soares; Vanessa Pinho; Humberto Torloni; Luiz F L Reis; Mauro M Teixeira; Adriana A M Dias; Mauro T Martins
Journal: Am J Pathol Date: 2002-05 Impact factor: 4.307

5. TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK.

Authors: Bing Han; Marco Mura; Cristiano F Andrade; Daisuke Okutani; Monika Lodyga; Claudia C dos Santos; Shaf Keshavjee; Michael Matthay; Mingyao Liu
Journal: J Immunol Date: 2005-12-15 Impact factor: 5.422

6. PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammation.

Authors: F Fazzini; G Peri; A Doni; G Dell'Antonio; E Dal Cin; E Bozzolo; F D'Auria; L Praderio; G Ciboddo; M G Sabbadini; A A Manfredi; A Mantovani; P R Querini
Journal: Arthritis Rheum Date: 2001-12

Review 7. C-reactive protein as a marker for inflammatory bowel disease.

Authors: Séverine Vermeire; Gert Van Assche; Paul Rutgeerts
Journal: Inflamm Bowel Dis Date: 2004-09 Impact factor: 5.325

8. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component.

Authors: F Breviario; E M d'Aniello; J Golay; G Peri; B Bottazzi; A Bairoch; S Saccone; R Marzella; V Predazzi; M Rocchi
Journal: J Biol Chem Date: 1992-11-05 Impact factor: 5.157

Review 9. Laboratory markers in IBD: useful, magic, or unnecessary toys?

Authors: S Vermeire; G Van Assche; P Rutgeerts
Journal: Gut Date: 2006-03 Impact factor: 23.059

10. The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps.

Authors: Sébastien Jaillon; Giuseppe Peri; Yves Delneste; Isabelle Frémaux; Andrea Doni; Federica Moalli; Cecilia Garlanda; Luigina Romani; Hugues Gascan; Silvia Bellocchio; Silvia Bozza; Marco A Cassatella; Pascale Jeannin; Alberto Mantovani
Journal: J Exp Med Date: 2007-03-26 Impact factor: 14.307

8 in total

1. Risk factors for chronic kidney diseases may include periodontal diseases, as estimated by the correlations of plasma pentraxin-3 levels: a case-control study.

Authors: A R Pradeep; Rahul Kathariya; P Arjun Raju; R Sushma Rani; Anuj Sharma; N M Raghavendra
Journal: Int Urol Nephrol Date: 2011-06-03 Impact factor: 2.370

2. Mucosal healing in inflammatory bowel disease: Maintain or de-escalate therapy.

Authors: Marcello Cintolo; Giuseppe Costantino; Socrate Pallio; Walter Fries
Journal: World J Gastrointest Pathophysiol Date: 2016-02-15

3. Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32.

Authors: Jianbin Yin; Hua Zeng; Kai Fan; Haoyu Xie; Yan Shao; Yuheng Lu; Jinjian Zhu; Zihao Yao; Liangliang Liu; Hongbo Zhang; Bingsheng Luo; Xinjie Wang; Chun Zeng; Xiaochun Bai; Haiyan Zhang; Daozhang Cai
Journal: Cell Death Dis Date: 2022-06-24 Impact factor: 9.685