Literature DB >> 1798958

Preclinical evaluation of 99m technetium-labeled DD-3B6/22 Fab' for thrombus detection.

K Z Walker1, G R Boniface, A F Phippard, W Harewood, G J Bautovich, P G Bundesen.   

Abstract

Injection of 99mTc-labeled Fab' fragments of the anti-fibrin antibody DD-3B6/22, in the baboon, resulted in clear visualisation of both fresh and aged autologous thrombi by gamma scintigraphy. Whole body scintigraphy, pharmacokinetics and urine analysis showed rapid renal excretion of the conjugate with little accumulation of label in other organs. 99mTc-DD-3B6/22 Fab' appears a suitable candidate for further investigation as a radioimaging agent for thrombi in humans.

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Year:  1991        PMID： 1798958     DOI： 10.1016/0049-3848(91)90069-9

Source DB:  PubMed          Journal:  Thromb Res        ISSN： 0049-3848            Impact factor:   3.944


  3 in total

1.  Imaging of deep venous thrombosis in patients using a radiolabelled anti-D-dimer Fab' fragment (99mTc-DI-DD3B6/22-80B3): results of a phase I trial.

Authors:  David Macfarlane; Angelides Socrates; Paul Eisenberg; George Larcos; Paul Roach; Michael Gerometta; Richard Smart; Wendy Tsui; Andrew M Scott
Journal:  Eur J Nucl Med Mol Imaging       Date:  2008-09-18       Impact factor: 9.236

Review 2.  The role of molecular imaging in diagnosis of deep vein thrombosis.

Authors:  Sina Houshmand; Ali Salavati; Søren Hess; Mudalsha Ravina; Abass Alavi
Journal:  Am J Nucl Med Mol Imaging       Date:  2014-08-15

3.  Safety, pharmacokinetic and dosimetry evaluation of the proposed thrombus imaging agent 99mTc-DI-DD-3B6/22-80B3 Fab'.

Authors:  David J Macfarlane; Richard C Smart; Wendy W Tsui; Michael Gerometta; Paul R Eisenberg; Andrew M Scott
Journal:  Eur J Nucl Med Mol Imaging       Date:  2006-03-10       Impact factor: 9.236
  3 in total

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