Literature DB >> 17988991

Successful all-trans retinoic acid treatment of acute promyelocytic leukemia in a patient with NPM/RAR fusion.

Kiyoshi Okazuka1, Masayoshi Masuko, Yoshinobu Seki, Hitomi Hama, Noriyuki Honma, Tatsuo Furukawa, Ken Toba, Kenji Kishi, Yoshifusa Aizawa.   

Abstract

Acute promyelocytic leukemia (APL) is characterized by a reciprocal chromosomal translocation involving the gene for retinoic acid receptor alpha(RAR). Most APL patients have a t(15;17) translocation that generates the PML-RAR fusion gene, and such patients respond well to treatment with all-trans retinoic acid (ATRA). Some APL cases also involve rearrangements that fuse RAR to partner genes other than PML, including nucleophosmin (NPM), promyelocytic leukemia zinc finger (PLZF), nuclear mitotic apparatus (NUMA), and Stat5b, but the clinical characteristics of APL without PML-RAR have not been fully clarified. We describe a 64-year-old man with NPM-RAR-positive APL who was receiving hemodialysis therapy for chronic uremia. Complete remission was achieved with ATRA monotherapy and was maintained for 18 months with consolidation chemotherapy. These findings suggest that ATRA can be used to treat APL patients with NPM/RAR as well as APL with PML/RAR.

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Year:  2007        PMID： 17988991     DOI： 10.1532/IJH97.07036

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  15 in total

1.  Pharmacokinetics of all-trans retinoic acid in acute promyelocytic leukemia patients on dialysis.

Authors:  Kimitaka Takitani; Koichi Nagai; Eiki Kanbe; Akiko Inoue; Chihiro Kawakami; Tomoko Kuno; Hiroshi Tamai
Journal:  Am J Hematol       Date:  2003-10       Impact factor: 10.047

2.  The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia.

Authors:  C Arnould; C Philippe; V Bourdon; M J Gr goire; R Berger; P Jonveaux
Journal:  Hum Mol Genet       Date:  1999-09       Impact factor: 6.150

3.  Molecular cytogenetic characterization and clinical relevance of additional, complex and/or variant chromosome abnormalities in acute promyelocytic leukemia.

Authors:  L Xu; W L Zhao; S M Xiong; X Y Su; M Zhao; C Wang; Y R Gao; C Niu; Q Cao; B W Gu; Y M Zhu; J Gu; J Hu; H Yan; Z X Shen; Z Chen; S J Chen
Journal:  Leukemia       Date:  2001-09       Impact factor: 11.528

4.  Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia.

Authors:  R A Wells; C Catzavelos; S Kamel-Reid
Journal:  Nat Genet       Date:  1997-09       Impact factor: 38.330

5.  The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties.

Authors:  R L Redner; J D Chen; E A Rush; H Li; S L Pollock
Journal:  Blood       Date:  2000-04-15       Impact factor: 22.113

6.  Acquired inv(9): what is its significance?

Authors:  Jaime L Betz; Ahmed S Behairy; Pedro Rabionet; Budi Tirtorahardjo; Mathew W Moore; Philip D Cotter
Journal:  Cancer Genet Cytogenet       Date:  2005-07-01

7.  The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.

Authors:  R L Redner; E A Rush; S Faas; W A Rudert; S J Corey
Journal:  Blood       Date:  1996-02-01       Impact factor: 22.113

8.  Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).

Authors:  J D Licht; C Chomienne; A Goy; A Chen; A A Scott; D R Head; J L Michaux; Y Wu; A DeBlasio; W H Miller
Journal:  Blood       Date:  1995-02-15       Impact factor: 22.113

9.  Population studies of INV(9) chromosomes in 4,300 Japanese: incidence, sex difference and clinical significance.

Authors:  K Yamada
Journal:  Jpn J Hum Genet       Date:  1992-12

10.  Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

Authors:  Z Chen; N J Brand; A Chen; S J Chen; J H Tong; Z Y Wang; S Waxman; A Zelent
Journal:  EMBO J       Date:  1993-03       Impact factor: 11.598
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  9 in total

1.  LG-362B targets PML-RARα and blocks ATRA resistance of acute promyelocytic leukemia.

Authors:  X Wang; Q Lin; F Lv; N Liu; Y Xu; M Liu; Y Chen; Z Yi
Journal:  Leukemia       Date:  2016-03-08       Impact factor: 11.528

2.  Successful treatment of acute promyelocytic leukemia in a patient on hemodialysis.

Authors:  Yoshiki Tsuchiya; Yoshifumi Ubara; Tatsuya Suwabe; Junichi Hoshino; Keiichi Sumida; Rikako Hiramatsu; Eiko Hasegawa; Masayuki Yamanouchi; Noriko Hayami; Yuji Marui; Naoki Sawa; Fumi Takemoto; Kenmei Takaichi
Journal:  Clin Exp Nephrol       Date:  2011-02-05       Impact factor: 2.801

3.  Relapsed APL patient with variant NPM-RARalpha fusion responded to arsenic trioxide-based therapy and achieved long-term survival.

Authors:  Yan Chen; Ling Gu; Chenyan Zhou; Xueqiang Wu; Ju Gao; Qiang Li; Yiping Zhu; Cangsong Jia; Zhigui Ma
Journal:  Int J Hematol       Date:  2010-04-20       Impact factor: 2.490

4.  Spontaneous regression of aleukemic leukemia cutis harboring a NPM/RARA fusion gene in an infant with cutaneous mastocytosis.

Authors:  Hirokazu Kanegane; Keiko Nomura; Akihiro Abe; Teruhiko Makino; Shin Ishizawa; Tadamichi Shimizu; Tomoki Naoe; Toshio Miyawaki
Journal:  Int J Hematol       Date:  2008-12-04       Impact factor: 2.490

Review 5.  A new transcriptional variant and small azurophilic granules in an acute promyelocytic leukemia case with NPM1/RARA fusion gene.

Authors:  Tomoe Kikuma; Yuji Nakamachi; Yoriko Noguchi; Yoko Okazaki; Daisuke Shimomura; Kimikazu Yakushijin; Katsuya Yamamoto; Hiroshi Matsuoka; Hironobu Minami; Tomoo Itoh; Seiji Kawano
Journal:  Int J Hematol       Date:  2015-09-05       Impact factor: 2.490

Review 6.  Molecules that target nucleophosmin for cancer treatment: an update.

Authors:  Adele Di Matteo; Mimma Franceschini; Sara Chiarella; Serena Rocchio; Carlo Travaglini-Allocatelli; Luca Federici
Journal:  Oncotarget       Date:  2016-07-12

Review 7.  PLZF-RARα, NPM1-RARα, and Other Acute Promyelocytic Leukemia Variants: The PETHEMA Registry Experience and Systematic Literature Review.

Authors:  Marta Sobas; Maria Carme Talarn-Forcadell; David Martínez-Cuadrón; Lourdes Escoda; María J García-Pérez; Jose Mariz; María J Mela-Osorio; Isolda Fernández; Juan M Alonso-Domínguez; Javier Cornago-Navascués; Gabriela Rodríguez-Macias; María E Amutio; Carlos Rodríguez-Medina; Jordi Esteve; Agnieszka Sokół; Thais Murciano-Carrillo; María J Calasanz; Manuel Barrios; Eva Barragán; Miguel A Sanz; Pau Montesinos
Journal:  Cancers (Basel)       Date:  2020-05-21       Impact factor: 6.639

Review 8.  Atypical Rearrangements in APL-Like Acute Myeloid Leukemias: Molecular Characterization and Prognosis.

Authors:  Luca Guarnera; Tiziana Ottone; Emiliano Fabiani; Mariadomenica Divona; Arianna Savi; Serena Travaglini; Giulia Falconi; Paola Panetta; Maria Cristina Rapanotti; Maria Teresa Voso
Journal:  Front Oncol       Date:  2022-04-12       Impact factor: 5.738

Review 9.  Classic and Variants APLs, as Viewed from a Therapy Response.

Authors:  Marie-Claude Geoffroy; Hugues de Thé
Journal:  Cancers (Basel)       Date:  2020-04-14       Impact factor: 6.639
  9 in total

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