| Literature DB >> 17988864 |
Mark D McBriar1, John W Clader, Inhou Chu, Robert A Del Vecchio, Leonard Favreau, William J Greenlee, Lynn A Hyde, Amin A Nomeir, Eric M Parker, Dmitri A Pissarnitski, Lixin Song, Lili Zhang, Zhiqiang Zhao.
Abstract
The design of amide and heteroaryl amide isosteres as replacements for the carbamate substructure in previously disclosed 2,6-disubstituted piperidine N-arylsulfonamides is described. In several cases, amides lessened CYP liabilities in this class of gamma-secretase inhibitors. Selected compounds showed significant reduction of Abeta levels upon oral dosing in a transgenic murine model of Alzheimer's disease.Entities:
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Year: 2007 PMID： 17988864 DOI： 10.1016/j.bmcl.2007.10.092
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823