| Literature DB >> 17988764 |
Bilal A Bhat1, P Bhaskar Reddy, Satyam Kumar Agrawal, A K Saxena, H M Sampath Kumar, G N Qazi.
Abstract
A series of 4beta-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxin congeners have been designed and synthesized with significant regioselectivity by employing Cu(I) catalyzed 1,3-dipolar cycloaddition reaction of C4beta-azido podophyllotoxin and C4beta-azido-4'-O-demethyl podophyllotoxin with N-prop-2-yn-1-ylanilines. These compounds were evaluated for anticancer activity against a panel of seven human cancer cell lines. It was interesting to note that all the compounds exhibited promising activity especially against SF-295 (CNS), HCT-15 (colon) and 502713 (colon) cell lines. Compound 11e was found to be the most promising in this study.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17988764 DOI： 10.1016/j.ejmech.2007.09.015
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514