| Literature DB >> 17988688 |
Lauren Myers1, Jennifer M Farmer, Robert B Wilson, Lisa Friedman, Amy Tsou, Susan L Perlman, Sub H Subramony, Christopher M Gomez, Tetsuo Ashizawa, George R Wilmot, Katherine D Mathews, Laura J Balcer, David R Lynch.
Abstract
Many antioxidants have been suggested as potential treatments for Friedreich ataxia, but have not been tested in clinical trials. We found that a majority of patients in our cohort already use such antioxidants, including idebenone, which is not available at a pharmaceutical grade in the United States. Younger age, cardiomyopathy and shorter GAA repeat length were independent predictors of idebenone use, but no factors predicted use of other antioxidants. This confirms that non-prescription antioxidant use represents a major confounder to formal trials of existing and novel agents for Friedreich ataxia.Entities:
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Year: 2007 PMID： 17988688 PMCID： PMC2279016 DOI： 10.1016/j.jns.2007.10.008
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181