Literature DB >> 17988130

Total synthesis and antibacterial properties of carbaplatensimycin.

K C Nicolaou1, Yefeng Tang, Jianhua Wang, Antonia F Stepan, Ang Li, Ana Montero.   

Abstract

The chemical synthesis and biological evaluation of carbaplatensimycin, the carbon analogue of the recently reported antibiotic platensimycin has been accomplished. Carbaplatensimycin exhibited similar potency to the natural product as an antibacterial agent against a variety of strains, including methicilin- and vancomycin-resistant bacteria.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17988130     DOI： 10.1021/ja076126e

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  23 in total

Review 1.  Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Authors:  K C Nicolaou; Christopher R H Hale; Christian Nilewski; Heraklidia A Ioannidou
Journal:  Chem Soc Rev       Date:  2012-06-28       Impact factor: 54.564

2.  Late-Stage Functionalization of Platensimycin Leading to Multiple Analogues with Improved Antibacterial Activity in Vitro and in Vivo.

Authors:  Youchao Deng; Xiang Weng; Yuling Li; Meng Su; Zhongqing Wen; Xinxin Ji; Nan Ren; Ben Shen; Yanwen Duan; Yong Huang
Journal:  J Med Chem       Date:  2019-07-02       Impact factor: 7.446

Review 3.  Recent advances in the chemistry and biology of naturally occurring antibiotics.

Authors:  K C Nicolaou; Jason S Chen; David J Edmonds; Anthony A Estrada
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

Review 4.  A brief history of antibiotics and select advances in their synthesis.

Authors:  Kyriacos C Nicolaou; Stephan Rigol
Journal:  J Antibiot (Tokyo)       Date:  2017-07-05       Impact factor: 2.649

Review 5.  Recent advances in ruthenium-based olefin metathesis.

Authors:  O M Ogba; N C Warner; D J O'Leary; R H Grubbs
Journal:  Chem Soc Rev       Date:  2018-06-18       Impact factor: 54.564

6.  Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine.

Authors:  K C Nicolaou; Stephan Rigol
Journal:  Nat Prod Rep       Date:  2020-04-22       Impact factor: 13.423

7.  Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions.

Authors:  Youchao Deng; Meng Su; Dingding Kang; Xingyun Liu; Zhongqing Wen; Yuling Li; Lin Qiu; Ben Shen; Yanwen Duan; Yong Huang
Journal:  J Med Chem       Date:  2018-12-05       Impact factor: 7.446

8.  Engineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners.

Authors:  Zhiguo Yu; Michael J Smanski; Ryan M Peterson; Karen Marchillo; David Andes; Scott R Rajski; Ben Shen
Journal:  Org Lett       Date:  2010-04-16       Impact factor: 6.005

9.  A symmetry-based concise formal synthesis of platencin, a novel lead against "superbugs".

Authors:  Arun K Ghosh; Kai Xi
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

10.  Total synthesis of platensimycin and related natural products.

Authors:  K C Nicolaou; Ang Li; David J Edmonds; G Scott Tria; Shelby P Ellery
Journal:  J Am Chem Soc       Date:  2009-11-25       Impact factor: 15.419
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.