| Literature DB >> 17988096 |
Malcolm S Buchanan1, Anthony R Carroll, Rama Addepalli, Vicky M Avery, John N A Hooper, Ronald J Quinn.
Abstract
The sponge Psammoclemma sp. was investigated as part of our studies to discover P2X 7 receptor antagonists for the treatment of inflammatory disease. The biological activity of this extract was found to be due to the cytotoxicity of two new bromotyrosine alkaloids, psammaplysenes C (1) and D (2), and not P2X 7-specific activity. Their structures were determined by 1D and 2D NMR spectroscopy.Entities:
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Year: 2007 PMID： 17988096 DOI： 10.1021/np0703646
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050