Recent developments in the chemistry, analysis and control for the manufacture of therapeutic-grade synthetic oligonucleotides.

Significant developments in oligonucleotide chemistry, which occurred between 1980 and 2000, led to several oligonucleotide-based therapeutics entering clinical trials. Improvements in synthesis and purification methods, along with analytical techniques have facilitated the large-scale manufacture of high quality oligonucleotides to support these clinical trials.