Intermittent dietary restriction as a practical intervention in aging.

Recent studies on the effects of dietary restriction (DR) in rodents and primates have shown that even late-onset short-term regimens can bring about comparable beneficial changes seen in animals subjected to life-long DR. We examined the effect of 3 months of DR on the expression of antioxidant enzymes and antioxidants, heat-shock protein 70 (HSP-70), neural cell adhesion molecule (NCAM) and its polysialylated form, PSA-NCAM, as well as astrocytic marker glial fibrillary acidic protein (GFAP) in 18-month-old middle-aged rats. The present study shows that DR initiated in late adulthood confers beneficial effects, such as attenuation of oxidative stress, enhanced expression of HSP-70, neural plasticity markers NCAM, and PSA-NCAM, and reduced levels of GFAP.