Literature DB >> 17986151

Alzheimer's disease: the lipid connection.

Tobias Hartmann1, Johannna Kuchenbecker, Marcus O W Grimm.   

Abstract

Alzheimer's disease is the most common neurodegenerative disorder. This short review summarizes the current knowledge about the role of lipids, especially cholesterol, sphingolipids, plasmalogens, and polyunsaturated fatty acids in Alzheimer's disease etiology, pathogenesis, risk-factors, prevention, treatment, and the function of the amyloid precursor protein and the amyloid peptides in lipid homeostasis.

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Year:  2007        PMID： 17986151     DOI： 10.1111/j.1471-4159.2007.04715.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  67 in total

1.  The BUME method: a novel automated chloroform-free 96-well total lipid extraction method for blood plasma.

Authors:  Lars Löfgren; Marcus Ståhlman; Gun-Britt Forsberg; Sinikka Saarinen; Ralf Nilsson; Göran I Hansson
Journal:  J Lipid Res       Date:  2012-05-29       Impact factor: 5.922

2.  Neurometabolic roles of ApoE and Ldl-R in mouse brain.

Authors:  Jieun Lee; Joseph Choi; G William Wong; Michael J Wolfgang
Journal:  J Bioenerg Biomembr       Date:  2015-12-21       Impact factor: 2.945

3.  Evidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor protein.

Authors:  Jun-Xia Lu; Wai-Ming Yau; Robert Tycko
Journal:  Biophys J       Date:  2011-02-02       Impact factor: 4.033

4.  Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness.

Authors:  Edith Winkler; Frits Kamp; Johannes Scheuring; Amelie Ebke; Akio Fukumori; Harald Steiner
Journal:  J Biol Chem       Date:  2012-04-24       Impact factor: 5.157

5.  Small molecule analysis and imaging of fatty acids in the zebra finch song system using time-of-flight-secondary ion mass spectrometry.

Authors:  Kensey R Amaya; Jonathan V Sweedler; David F Clayton
Journal:  J Neurochem       Date:  2011-05-19       Impact factor: 5.372

6.  Electron tomography of early melanosomes: implications for melanogenesis and the generation of fibrillar amyloid sheets.

Authors:  Ilse Hurbain; Willie J C Geerts; Thomas Boudier; Sergio Marco; Arie J Verkleij; Michael S Marks; Graç Raposo
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-25       Impact factor: 11.205

7.  Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathways.

Authors:  Pavel Michal; Vladimír Rudajev; Esam E El-Fakahany; Vladimír Dolezal
Journal:  Eur J Pharmacol       Date:  2009-01-29       Impact factor: 4.432

Review 8.  Beta-secretase: structure, function, and evolution.

Authors:  Chitra Venugopal; Christina M Demos; K S Jagannatha Rao; Miguel A Pappolla; Kumar Sambamurti
Journal:  CNS Neurol Disord Drug Targets       Date:  2008-06       Impact factor: 4.388

9.  How cholesterol constrains glycolipid conformation for optimal recognition of Alzheimer's beta amyloid peptide (Abeta1-40).

Authors:  Nouara Yahi; Anaïs Aulas; Jacques Fantini
Journal:  PLoS One       Date:  2010-02-05       Impact factor: 3.240

10.  Cardiovascular dementia - a different perspective.

Authors:  Udhaya Kumari; Klaus Heese
Journal:  Open Biochem J       Date:  2010-03-26
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