OBJECTIVES: To determine whether myocardial contrast echocardiography (MCE) can quickly and accurately assess myocardial perfusion and infarct-related artery (IRA) patency before emergency angiography during acute myocardial infarction (AMI). BACKGROUND: Despite encouraging experimental and clinical studies, the reliability and practicality of MCE in predicting IRA patency during AMI before angiography has not been proven. METHODS: Two-dimensional echocardiography and MCE were performed in 51 patients with AMI just before emergency angiography. With knowledge of the electrocardiogram findings and regional wall motion, myocardial perfusion was assessed to predict IRA patency. RESULTS: Myocardial perfusion studies were adequate for interpretation in 40 patients. An occluded IRA was predicted in 28 patients; the artery was occluded in 22 patients, and six patients had Thrombolysis In Myocardial Infarction (TIMI) grade 2 flow or less. A patent IRA was predicted in 12 patients; eight patients had TIMI grade 3 flow, one patient had TIMI grade 2 flow and the IRA was occluded in three patients. In one of the three patients, the appropriate view was not obtained. In another patient, collateral flow was adequate for near-normal regional wall motion, and in the last, the findings suggested reperfusion of the proximal artery with distal embolic occlusion. Taken together, MCE accurately predicted either TIMI grade 2 flow or less, or TIMI grade 3 flow in 36 of 40 patients. Sensitivity was 87.5%, specificity and positive predictive value were 100% and negative predictive power was 66.7% (P<0.001). CONCLUSIONS: MCE, together with the electrocardiogram and regional wall motion, can be used to quickly and reliably predict IRA patency early during AMI and may be useful to facilitate a management strategy.
OBJECTIVES: To determine whether myocardial contrast echocardiography (MCE) can quickly and accurately assess myocardial perfusion and infarct-related artery (IRA) patency before emergency angiography during acute myocardial infarction (AMI). BACKGROUND: Despite encouraging experimental and clinical studies, the reliability and practicality of MCE in predicting IRA patency during AMI before angiography has not been proven. METHODS: Two-dimensional echocardiography and MCE were performed in 51 patients with AMI just before emergency angiography. With knowledge of the electrocardiogram findings and regional wall motion, myocardial perfusion was assessed to predict IRA patency. RESULTS: Myocardial perfusion studies were adequate for interpretation in 40 patients. An occluded IRA was predicted in 28 patients; the artery was occluded in 22 patients, and six patients had Thrombolysis In Myocardial Infarction (TIMI) grade 2 flow or less. A patent IRA was predicted in 12 patients; eight patients had TIMI grade 3 flow, one patient had TIMI grade 2 flow and the IRA was occluded in three patients. In one of the three patients, the appropriate view was not obtained. In another patient, collateral flow was adequate for near-normal regional wall motion, and in the last, the findings suggested reperfusion of the proximal artery with distal embolic occlusion. Taken together, MCE accurately predicted either TIMI grade 2 flow or less, or TIMI grade 3 flow in 36 of 40 patients. Sensitivity was 87.5%, specificity and positive predictive value were 100% and negative predictive power was 66.7% (P<0.001). CONCLUSIONS: MCE, together with the electrocardiogram and regional wall motion, can be used to quickly and reliably predict IRA patency early during AMI and may be useful to facilitate a management strategy.
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Authors: Anthony H Gershlick; Amanda Stephens-Lloyd; Sarah Hughes; Keith R Abrams; Suzanne E Stevens; Neal G Uren; Adam de Belder; John Davis; Michael Pitt; Adrian Banning; Andreas Baumbach; Man Fai Shiu; Peter Schofield; Keith D Dawkins; Robert A Henderson; Keith G Oldroyd; Robert Wilcox Journal: N Engl J Med Date: 2005-12-29 Impact factor: 91.245
Authors: J K French; T A Hyde; I T Straznicky; J Andrews; M Lund; D J Amos; A Zambanini; C J Ellis; B J Webber; S C McLaughlin; R M Whitlock; S O Manda; H Patel; H D White Journal: J Am Coll Cardiol Date: 2000-05 Impact factor: 24.094
Authors: A M Ross; K S Coyne; J S Reiner; S W Greenhouse; C Fink; A Frey; E Moreyra; M Traboulsi; N Racine; A L Riba; M A Thompson; S Rohrbeck; C F Lundergan Journal: J Am Coll Cardiol Date: 1999-12 Impact factor: 24.094
Authors: K Iwakura; H Ito; S Kawano; Y Shintani; K Yamamoto; A Kato; M Ikushima; K Tanaka; M Kitakaze; M Hori; Y Higashino; K Fujii Journal: J Am Coll Cardiol Date: 2001-08 Impact factor: 24.094
Authors: O Kamp; W Lepper; J L Vanoverschelde; B C Aeschbacher; D Rovai; P Assayag; P Voci; Y Kloster; A Distante; C A Visser Journal: Eur Heart J Date: 2001-08 Impact factor: 29.983
Authors: J A de Lemos; E M Antman; R P Giugliano; C H McCabe; S A Murphy; F Van de Werf; C M Gibson; E Braunwald Journal: Am J Cardiol Date: 2000-02-01 Impact factor: 2.778
Authors: A Shah; G S Wagner; C B Granger; C M O'Connor; C L Green; K M Trollinger; R M Califf; M W Krucoff Journal: J Am Coll Cardiol Date: 2000-03-01 Impact factor: 24.094