BACKGROUND: Cardiovascular diseases account for nearly 20% of all hospitalizations in Canada and consume 12% of the total cost of all illnesses. With increasing trends of cardiovascular disease and increasing costs of care, development of cost-effective strategies is vital. The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial demonstrated the effectiveness of clopidogrel plus acetylsalicylic acid (ASA) compared with ASA alone in reducing cardiovascular events in patients with acute coronary syndromes and, in addition, patients undergoing percutaneous coronary intervention in the Percutaneous Coronary Intervention in CURE (PCI-CURE) trial. OBJECTIVE: To assess the cost-effectiveness of clopidogrel in the Canadian health care system. METHODS: Estimates of hospitalization costs were based on the 2003 cost schedules released by the Health Funding and Costing Branch of the Alberta Health and Wellness, as well as on the Case Mix Group classification system. Life expectancy beyond the trial was estimated from the Saskatchewan Health Database. Cost-effectiveness was expressed as the incremental cost-effectiveness ratio, and bootstrap methods were used to estimate the joint distribution of costs and effectiveness. RESULTS:Clopidogrel was shown to be cost-effective, with incremental cost-effectiveness ratios less than $10,000 per event prevented and less than $4,000 per life-year gained. The probability of clopidogrel resulting in cost per life-year gained of less than $20,000 was 0.975 for CURE patients and 0.904 for PCI-CURE patients. CONCLUSIONS: The economic analysis demonstrated that clopidogrel combination therapy is not only cost-effective as antiplatelet therapy compared with ASA alone, but it is also cost-effective compared with other commonly used and openly reimbursed cardiovascular therapies in the Canadian health care system.
RCT Entities:
BACKGROUND:Cardiovascular diseases account for nearly 20% of all hospitalizations in Canada and consume 12% of the total cost of all illnesses. With increasing trends of cardiovascular disease and increasing costs of care, development of cost-effective strategies is vital. The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial demonstrated the effectiveness of clopidogrel plus acetylsalicylic acid (ASA) compared with ASA alone in reducing cardiovascular events in patients with acute coronary syndromes and, in addition, patients undergoing percutaneous coronary intervention in the Percutaneous Coronary Intervention in CURE (PCI-CURE) trial. OBJECTIVE: To assess the cost-effectiveness of clopidogrel in the Canadian health care system. METHODS: Estimates of hospitalization costs were based on the 2003 cost schedules released by the Health Funding and Costing Branch of the Alberta Health and Wellness, as well as on the Case Mix Group classification system. Life expectancy beyond the trial was estimated from the Saskatchewan Health Database. Cost-effectiveness was expressed as the incremental cost-effectiveness ratio, and bootstrap methods were used to estimate the joint distribution of costs and effectiveness. RESULTS:Clopidogrel was shown to be cost-effective, with incremental cost-effectiveness ratios less than $10,000 per event prevented and less than $4,000 per life-year gained. The probability of clopidogrel resulting in cost per life-year gained of less than $20,000 was 0.975 for CURE patients and 0.904 for PCI-CURE patients. CONCLUSIONS: The economic analysis demonstrated that clopidogrel combination therapy is not only cost-effective as antiplatelet therapy compared with ASA alone, but it is also cost-effective compared with other commonly used and openly reimbursed cardiovascular therapies in the Canadian health care system.
Authors: Johanna N Spaans; Douglas Coyle; George Fodor; Rama Nair; Régis Vaillancourt; Steven A Grover; Louis Coupal Journal: Can J Cardiol Date: 2003-06 Impact factor: 5.223
Authors: William S Weintraub; Elizabeth M Mahoney; Andre Lamy; Steven Culler; Yong Yuan; Jaime Caro; Sylvie Gabriel; Salim Yusuf Journal: J Am Coll Cardiol Date: 2005-03-15 Impact factor: 24.094
Authors: S R Mehta; S Yusuf; R J Peters; M E Bertrand; B S Lewis; M K Natarajan; K Malmberg; H Rupprecht; F Zhao; S Chrolavicius; I Copland; K A Fox Journal: Lancet Date: 2001-08-18 Impact factor: 79.321
Authors: Elizabeth M Mahoney; Claudine T Jurkovitz; Haitao Chu; Edmund R Becker; Steven Culler; Andrzej S Kosinski; Debbie H Robertson; Charles Alexander; Soma Nag; John R Cook; Laura A Demopoulos; Peter M DiBattiste; Christopher P Cannon; William S Weintraub Journal: JAMA Date: 2002-10-16 Impact factor: 56.272
Authors: Andre Lamy; Bengt Jönsson; William S Weintraub; Feng Zhao; Susan Chrolavicius; Ameet Bakhai; Steven Culler; Amiram Gafni; Peter Lindgren; Elizabeth Mahoney; Salim Yusuf Journal: Eur J Cardiovasc Prev Rehabil Date: 2004-12