Literature DB >> 1798288

Role of iron and oxygen radicals in hemorrhage and shock.

B E Hedlund1, P E Hallaway.   

Abstract

This contribution focuses on the role of iron as a critical component in the genesis of oxygen radical mediated tissue injury occurring after global ischemia associated with severe hypovolemic shock. Conventional colloid or crystalloid fluid resuscitation does not adequately protect organs susceptible to reperfusion injury. One approach aimed at attenuating such post-trauma reperfusion injury is systemic, high dose, iron chelation used in combination with colloid fluid replacement.

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Year:  1991        PMID： 1798288     DOI： 10.1007/BF01645169

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  34 in total

1.  Mechanism of release of ferritin iron in vivo by xanthine oxidase.

Authors:  A MAZUR; S GREEN; A SAHA; A CARLETON
Journal:  J Clin Invest       Date:  1958-12       Impact factor: 14.808

2.  The iron chelator desferrioxamine attenuates postischemic ventricular dysfunction.

Authors:  R Bolli; B S Patel; W X Zhu; P G O'Neill; C J Hartley; M L Charlat; R Roberts
Journal:  Am J Physiol       Date:  1987-12

3.  Ferritin and superoxide-dependent lipid peroxidation.

Authors:  C E Thomas; L A Morehouse; S D Aust
Journal:  J Biol Chem       Date:  1985-03-25       Impact factor: 5.157

4.  Iron chelation with a deferoxamine conjugate in hemorrhagic shock.

Authors:  D M Jacobs; J M Julsrud; M P Bubrick
Journal:  J Surg Res       Date:  1991-12       Impact factor: 2.192

5.  Effects of hydroxyethyl starch conjugated deferoxamine on myocardial functional recovery following coronary occlusion and reperfusion in dogs.

Authors:  M Maruyama; G M Pieper; B Kalyanaraman; P E Hallaway; B E Hedlund; G J Gross
Journal:  J Cardiovasc Pharmacol       Date:  1991-01       Impact factor: 3.105

6.  Treatment with deferoxamine during ischemia improves functional and metabolic recovery and reduces reperfusion-induced oxygen radical generation in rabbit hearts.

Authors:  R E Williams; J L Zweier; J T Flaherty
Journal:  Circulation       Date:  1991-03       Impact factor: 29.690

7.  Conjugated desferoxamine attenuates hepatic microvascular injury following ischemia/reperfusion.

Authors:  G T Drugas; C N Paidas; A M Yahanda; D Ferguson; M G Clemens
Journal:  Circ Shock       Date:  1991-06

8.  Protection by desferrioxamine against histopathological changes of the liver in the post-oligaemic phase of clinical haemorrhagic shock in dogs: correlation with improved survival rate and recovery.

Authors:  S Sanan; G Sharma; R Malhotra; D P Sanan; P Jain; P Vadhera
Journal:  Free Radic Res Commun       Date:  1989

9.  Evidence for a role of iron-catalyzed oxidants in functional and metabolic stunning in the canine heart.

Authors:  N E Farber; G M Vercellotti; H S Jacob; G M Pieper; G J Gross
Journal:  Circ Res       Date:  1988-08       Impact factor: 17.367

10.  Acute iron poisoning. Rescue with macromolecular chelators.

Authors:  J R Mahoney; P E Hallaway; B E Hedlund; J W Eaton
Journal:  J Clin Invest       Date:  1989-10       Impact factor: 14.808
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  1 in total

1.  Genetic analysis of iron citrate toxicity in yeast: implications for mammalian iron homeostasis.

Authors:  Opal S Chen; Shawn Hemenway; Jerry Kaplan
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-06       Impact factor: 11.205
  1 in total

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