| Literature DB >> 17982648 |
M Hidalgo-Pascual1, J J Galan, M Chaves-Conde, J A Ramírez-Armengol, C Moreno, E Calvo, P Pelaez, C Crespo, A Ruiz, J L Royo.
Abstract
Colorectal cancer is one of the most prevalent cancers in developed countries. However, the genetic factors influencing its appearance remain far from being fully characterized. Recently, a G>A functional transition mapping the 3' untranslated region of the CXCL12 gene (rs1801157) has been found to be under-represented among rectal cancer patients when compared to colon cancer patients from a Swedish series. Here we present the results from an independent analysis of CXCL12 rs1801157 in a larger CRC series of Spanish origin in order to analyse the robustness of this association within a different European population. No significant difference was observed between controls and colon or rectal cancer patients. We were also unable to find a correlation between rs1801157 and different prognostic markers such as metastasis development or disease-free survival time. The epidemiologic data involving CXCL12 rs1801157 in colorectal cancer risk are discussed.Entities:
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Year: 2007 PMID： 17982648 DOI： 10.3892/or.18.6.1583
Source DB: PubMed Journal: Oncol Rep ISSN： 1021-335X Impact factor: 3.906