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Literature DB >> 17981463

Substrate specificity and screening of the integral membrane protease Pla.

Anton Agarkov¹, Sadhana Chauhan, Pedro J Lory, Scott R Gilbertson, Vladimir L Motin.

Abstract

This paper reports a study to find small peptide substrates for the important virulence factor of Yersinia pestis, plasminogen activator, Pla. The method used to find small substrates for this protease is reported along with studies examining the ability of these peptides to inhibit activity of the enzyme. Through the use of parallel synthesis and positional scanning, small tripeptides were identified that are viable substrates for the protease.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17981463 PMCID： PMC2263006 DOI： 10.1016/j.bmcl.2007.09.104

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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