| Literature DB >> 17981462 |
Pierre Verhaeghe1, Nadine Azas, Monique Gasquet, Sébastien Hutter, Christophe Ducros, Michèle Laget, Sylvain Rault, Pascal Rathelot, Patrice Vanelle.
Abstract
A series of original 4-aryl-substituted 2-trichloromethylquinazoline derivatives was synthesized using a microwave-assisted Suzuki-Miyaura cross-coupling approach. Antiplasmodial activity was evaluated on both chloroquino-resistant and -sensitive Plasmodium falciparum strains, and the selectivity indexes for THP1 and HepG2 human cells were also calculated, revealing their antiplasmodial potential.Entities:
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Year: 2007 PMID： 17981462 DOI： 10.1016/j.bmcl.2007.10.027
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823