| Literature DB >> 17981461 |
Richard M Angell1, Tony D Angell, Paul Bamborough, David Brown, Murray Brown, Jacky B Buckton, Stuart G Cockerill, Chris D Edwards, Katherine L Jones, Tim Longstaff, Penny A Smee, Kathryn J Smith, Don O Somers, Ann L Walker, Malcolm Willson.
Abstract
The biphenyl amides are a novel series of p38 MAP kinase inhibitors. Structure-activity relationships of the series against p38alpha are discussed with reference to the X-ray crystal structure of an example. The series was optimised rapidly to a compound showing oral activity in an in vivo disease model.Entities:
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Year: 2007 PMID： 17981461 DOI： 10.1016/j.bmcl.2007.10.043
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823