Marlene P Freeman1, Priti Sinha. 1. Women's Mental Health Center, Department of Psychiatry, Obstetrics and Gynecology, University of Texas--Southwestern Medical Center at Dallas, 6363 Forest Park, Suite 800, Dallas, TX 75235 9086, USA. marlene.freeman@utsouthwestern.edu
Abstract
BACKGROUND: Benefits of omega-3 fatty acids in perinatal women are well documented, although fish intake has declined among perinatal women. OBJECTIVE: To determine the tolerability of omega-3 fatty acid supplementation in perinatal women. DESIGN:Pregnant and postpartum women with major depressive disorder (MDD) entered an 8-week double-blind, placebo-controlled trial of omega-3 fatty acids. Four capsules provided 1.84 g/day of eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA), or matching placebo (corn oil with 1% fish oil to maintain blind). Tolerability was assessed by clinician interview biweekly. RESULTS:Fifty-nine women enrolled. Thirteen (22%) reported mainly transient side effects including dizziness, diarrhea, nausea, burping, heartburn/reflux, difficulty swallowing capsules, unpleasant breath/bad taste or feeling tired. The most common were unpleasant breath/bad taste and heartburn/reflux. Six reporting side effects received omega-3 fatty acids; seven received placebo. Neither pregnant nor postpartum women discontinued due to intolerability. CONCLUSIONS:Omega-3 fatty acid supplements were well tolerated by perinatal women.
RCT Entities:
BACKGROUND: Benefits of omega-3 fatty acids in perinatal women are well documented, although fish intake has declined among perinatal women. OBJECTIVE: To determine the tolerability of omega-3 fatty acid supplementation in perinatal women. DESIGN: Pregnant and postpartum women with major depressive disorder (MDD) entered an 8-week double-blind, placebo-controlled trial of omega-3 fatty acids. Four capsules provided 1.84 g/day of eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA), or matching placebo (corn oil with 1% fish oil to maintain blind). Tolerability was assessed by clinician interview biweekly. RESULTS: Fifty-nine women enrolled. Thirteen (22%) reported mainly transient side effects including dizziness, diarrhea, nausea, burping, heartburn/reflux, difficulty swallowing capsules, unpleasant breath/bad taste or feeling tired. The most common were unpleasant breath/bad taste and heartburn/reflux. Six reporting side effects received omega-3 fatty acids; seven received placebo. Neither pregnant nor postpartum women discontinued due to intolerability. CONCLUSIONS:Omega-3 fatty acid supplements were well tolerated by perinatal women.
Authors: David Mischoulon; George I Papakostas; Christina M Dording; Amy H Farabaugh; Shamsah B Sonawalla; A Monica Agoston; Juliana Smith; Erin C Beaumont; Liat E Dahan; Jonathan E Alpert; Andrew A Nierenberg; Maurizio Fava Journal: J Clin Psychiatry Date: 2009-08-25 Impact factor: 4.384
Authors: Paula S Silva; Gilberto Marcelo Sperandio da Silva; Andréa P de Souza; Claudia S A Cardoso; Cristiane A Fonseca; Patricia D Brito; Roberto M Saraiva; Pedro E A Brasil; Roberta O Pinheiro; Alejandro M Hasslocher-Moreno; Sérgio S Xavier; Andréa S Sousa Journal: Trials Date: 2013-11-11 Impact factor: 2.279