Literature DB >> 17981226

The role of the woodchuck model in the treatment of hepatitis B virus infection.

Ketan Kulkarni1, Ira M Jacobson, Bud C Tennant.   

Abstract

Experimental studies of animals with chronic hepadnavirus infection could provide valuable insight into optimal therapeutic strategies for individuals with chronic HBV infection. In this review, we focus on the contributions of the woodchuck model to our understanding of HBV biology and on its role in the development of antiviral drug. Furthermore, we consider the implications of studies focusing on the natural history of WHV infection for the management of HBV and the capacity of treatment to prevent complications of chronic hepatitis B infection.

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Year:  2007        PMID： 17981226     DOI： 10.1016/j.cld.2007.08.012

Source DB:  PubMed          Journal:  Clin Liver Dis        ISSN： 1089-3261            Impact factor:   6.126


  8 in total

1.  Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation.

Authors:  Dawei Cai; Courtney Mills; Wenquan Yu; Ran Yan; Carol E Aldrich; Jeffry R Saputelli; William S Mason; Xiaodong Xu; Ju-Tao Guo; Timothy M Block; Andrea Cuconati; Haitao Guo
Journal:  Antimicrob Agents Chemother       Date:  2012-05-29       Impact factor: 5.191

2.  Structurally similar woodchuck and human hepadnavirus core proteins have distinctly different temperature dependences of assembly.

Authors:  Alexander A Kukreja; Joseph C-Y Wang; Elizabeth Pierson; David Z Keifer; Lisa Selzer; Zhenning Tan; Bogdan Dragnea; Martin F Jarrold; Adam Zlotnick
Journal:  J Virol       Date:  2014-09-24       Impact factor: 5.103

3.  Novel Woodchuck Hepatitis Virus (WHV) transgene mouse models show sex-dependent WHV replicative activity and development of spontaneous immune responses to WHV proteins.

Authors:  Zhongji Meng; Zhiyong Ma; Ejuan Zhang; Anna D Kosinska; Jia Liu; Xiaoyong Zhang; Tianlun Zhou; Jun Wu; Uta Dahmen; Olaf Dirsch; Dongliang Yang; Michael Roggendorf; Mengji Lu
Journal:  J Virol       Date:  2013-11-20       Impact factor: 5.103

Review 4.  Modeling hepatitis B virus infection, immunopathology and therapy in mice.

Authors:  Liang Cheng; Feng Li; Moses T Bility; Christopher M Murphy; Lishan Su
Journal:  Antiviral Res       Date:  2015-06-19       Impact factor: 5.970

Review 5.  Stem cell origins and animal models of hepatocellular carcinoma.

Authors:  Rajagopal N Aravalli; Clifford J Steer; M Behnan Sahin; Erik N K Cressman
Journal:  Dig Dis Sci       Date:  2009-06-10       Impact factor: 3.199

Review 6.  Animal models of cancer in interventional radiology.

Authors:  Rajagopal N Aravalli; Jafar Golzarian; Erik N K Cressman
Journal:  Eur Radiol       Date:  2009-01-10       Impact factor: 5.315

7.  Liver cell transformation in chronic HBV infection.

Authors:  Shirine Benhenda; Delphine Cougot; Christine Neuveut; Marie Annick Buendia
Journal:  Viruses       Date:  2009-10-30       Impact factor: 5.818

Review 8.  New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems.

Authors:  Matthew R Pennington; Eric C Ledbetter; Gerlinde R Van de Walle
Journal:  Viruses       Date:  2017-11-18       Impact factor: 5.048
  8 in total

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