| Literature DB >> 17981155 |
Christina N Mork1, Douglas V Faller, Remco A Spanjaard.
Abstract
Expression of p53-target gene EI24/PIG8 is lost in invasive breast cancers, suggesting that EI24/PIG8 is a tumor suppressor that prevents tumor spreading, and partially mediates p53-attributed tumor suppressor activity. EI24/PIG8 also has pro-apoptotic activity indicating that loss of EI24/PIG8 may modulate sensitivity to chemotherapy. Here it is demonstrated that suppression of EI24/PIG8 in fibroblasts and breast cancer cells significantly inhibits the apoptotic response to etoposide treatment. These findings suggest that loss of EI24/PIG8 contributes significantly to resistance of cells to chemotherapeutic agents that function through p53, and identify the EI24/PIG8 status as a potentially new prognostic marker of chemotherapy responsiveness.Entities:
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Year: 2007 PMID： 17981155 PMCID： PMC2128731 DOI： 10.1016/j.febslet.2007.10.046
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124