| Literature DB >> 17981111 |
Abstract
Hypoxia, a condition of severe oxygen shortage, induces a transcriptional response that is important for both normal embryonic development and the growth of tumors. In this issue, Cheng et al. (2007) describe how the stability of the major transcriptional regulator of the hypoxic response, HIF1alpha, is modulated by the interplay between the ubiquitin and the SUMO conjugation systems.Entities:
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Year: 2007 PMID： 17981111 DOI： 10.1016/j.cell.2007.10.026
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582