Literature DB >> 17980587

Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase.

Ricardo Lira1, Alan X Xiang, Thomas Doundoulakis, William T Biller, Konstantinos A Agrios, Klaus B Simonsen, Stephen E Webber, Wes Sisson, Robert M Aust, Amit M Shah, Richard E Showalter, Virginia N Banh, Kevin R Steffy, James R Appleman.   

Abstract

Based upon observations from our initial findings, additional myxopyronin B analogs have been prepared and tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against Escherichia coli and Staphylococcus aureus.

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Year:  2007        PMID： 17980587     DOI： 10.1016/j.bmcl.2007.10.017

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Influence of DNA template choice on transcription and inhibition of Escherichia coli RNA polymerase.

Authors:  Joerg Haupenthal; Kristina Hüsecken; Matthias Negri; Christine K Maurer; Rolf W Hartmann
Journal:  Antimicrob Agents Chemother       Date:  2012-06-04       Impact factor: 5.191

2.  Novel hybrid-type antimicrobial agents targeting the switch region of bacterial RNA polymerase.

Authors:  Fumika Yakushiji; Yuko Miyamoto; Yuki Kunoh; Reiko Okamoto; Hidemasa Nakaminami; Yuri Yamazaki; Norihisa Noguchi; Yoshio Hayashi
Journal:  ACS Med Chem Lett       Date:  2013-01-11       Impact factor: 4.345

3.  Transcription inactivation through local refolding of the RNA polymerase structure.

Authors:  Georgiy A Belogurov; Marina N Vassylyeva; Anastasiya Sevostyanova; James R Appleman; Alan X Xiang; Ricardo Lira; Stephen E Webber; Sergiy Klyuyev; Evgeny Nudler; Irina Artsimovitch; Dmitry G Vassylyev
Journal:  Nature       Date:  2008-10-22       Impact factor: 49.962

Review 4.  New target for inhibition of bacterial RNA polymerase: 'switch region'.

Authors:  Aashish Srivastava; Meliza Talaue; Shuang Liu; David Degen; Richard Y Ebright; Elena Sineva; Anirban Chakraborty; Sergey Y Druzhinin; Sujoy Chatterjee; Jayanta Mukhopadhyay; Yon W Ebright; Alex Zozula; Juan Shen; Sonali Sengupta; Rui Rong Niedfeldt; Cai Xin; Takushi Kaneko; Herbert Irschik; Rolf Jansen; Stefano Donadio; Nancy Connell; Richard H Ebright
Journal:  Curr Opin Microbiol       Date:  2011-08-19       Impact factor: 7.934

5.  Structure-based ligand design of novel bacterial RNA polymerase inhibitors.

Authors:  Martin J McPhillie; Rachel Trowbridge; Katherine R Mariner; Alex J O'Neill; A Peter Johnson; Ian Chopra; Colin W G Fishwick
Journal:  ACS Med Chem Lett       Date:  2011-07-29       Impact factor: 4.345

6.  In vitro reconstitution of α-pyrone ring formation in myxopyronin biosynthesis.

Authors:  H Sucipto; J H Sahner; E Prusov; S C Wenzel; R W Hartmann; J Koehnke; R Müller
Journal:  Chem Sci       Date:  2015-05-18       Impact factor: 9.825

7.  The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in Staphylococcus aureus.

Authors:  Jan Balansky; Kenneth Pfarr; Christiane Szekat; Stefan Kehraus; Tilman Aden; Miriam Grosse; Rolf Jansen; Thomas Hesterkamp; Andrea Schiefer; Gabriele M König; Marc Stadler; Achim Hoerauf; Gabriele Bierbaum
Journal:  Antibiotics (Basel)       Date:  2022-07-08

8.  The RNA polymerase "switch region" is a target for inhibitors.

Authors:  Jayanta Mukhopadhyay; Kalyan Das; Sajida Ismail; David Koppstein; Minyoung Jang; Brian Hudson; Stefan Sarafianos; Steven Tuske; Jay Patel; Rolf Jansen; Herbert Irschik; Eddy Arnold; Richard H Ebright
Journal:  Cell       Date:  2008-10-17       Impact factor: 41.582
  8 in total

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