| Literature DB >> 17980586 |
Kumiko Takeuchi1, William G Holloway, Charles H Mitch, Steven J Quimby, Jamie H McKinzie, Todd M Suter, Michael A Statnick, Peggy L Surface, Paul J Emmerson, Elizabeth M Thomas, Miles G Siegel.
Abstract
A series of 6-bicycloaryloxynicotinamides were identified as opioid receptor antagonists at mu, kappa, and delta receptors. Compounds in the 6-(2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxy)nicotinamide scaffold exhibited potent in vitro functional antagonism at all three receptors.Entities:
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Year: 2007 PMID： 17980586 DOI： 10.1016/j.bmcl.2007.10.025
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823