Naoki Inui1, Takafumi Suda, Kingo Chida. 1. The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan. inui@hama-med.ac.jp
Abstract
BACKGROUND AND OBJECTIVE: Mycobacterium tuberculosis has been proposed as a candidate agent for the cause of sarcoidosis. The QuantiFERON-TB Gold test has a higher specificity for detecting M. tuberculosis infection than the conventional tuberculin skin test. This study aimed to investigate the rate of positive QuantiFERON-TB Gold results in Japanese sarcoidosis patients. PATIENTS AND METHODS: The QuantiFERON-TB Gold test, an enzyme-linked immunosorbent assay, was used to assess the levels of interferon-gamma resulting from immune responses to M. tuberculosis-specific antigens, namely early secretory antigen target 6 and culture filtrate protein 10, in 90 Japanese sarcoidosis patients. RESULTS: The QuantiFERON-TB Gold result was positive in 3 of the 90 patients tested. CONCLUSION: The positivity rate of QuantiFERON-TB Gold was 3.3% in Japanese sarcoidosis patients.
BACKGROUND AND OBJECTIVE:Mycobacterium tuberculosis has been proposed as a candidate agent for the cause of sarcoidosis. The QuantiFERON-TB Gold test has a higher specificity for detecting M. tuberculosis infection than the conventional tuberculin skin test. This study aimed to investigate the rate of positive QuantiFERON-TB Gold results in Japanese sarcoidosispatients. PATIENTS AND METHODS: The QuantiFERON-TB Gold test, an enzyme-linked immunosorbent assay, was used to assess the levels of interferon-gamma resulting from immune responses to M. tuberculosis-specific antigens, namely early secretory antigen target 6 and culture filtrate protein 10, in 90 Japanese sarcoidosispatients. RESULTS: The QuantiFERON-TB Gold result was positive in 3 of the 90 patients tested. CONCLUSION: The positivity rate of QuantiFERON-TB Gold was 3.3% in Japanese sarcoidosispatients.
Authors: Anna Starshinova; Yu Zinchenko; M Filatov; N Denisova; E Istomina; S Landa; V Burdakov; L Churilov; N Sapozhnikova; M Pavlova; T Stepanenko; V Mayevskaya; P Yablonskiy Journal: Immunol Res Date: 2018-12 Impact factor: 2.829
Authors: Muhunthan Thillai; Christian Eberhardt; Alex M Lewin; Lee Potiphar; Suzie Hingley-Wilson; Saranya Sridhar; Jonathan Macintyre; Onn Min Kon; Melissa Wickremasinghe; Athol Wells; Mark E Weeks; Donald Mitchell; Ajit Lalvani Journal: PLoS One Date: 2012-07-16 Impact factor: 3.240