Literature DB >> 17979803

High-speed screening and quantitative SAR analysis of human ABC transporter ABCG2 for molecular modeling of anticancer drugs to circumvent multidrug resistance.

H Saito1, H Hirano, T Ishikawa.   

Abstract

The transport mechanism-based molecular design strategy would provide an effective tool for rationalized chemotherapy against tumors. To develop a platform for molecular modeling to circumvent multidrug resistance, we established new methods of high-speed screening for human ABCG2-drug interactions, quantitative structure-activity relationship (QSAR) analysis, and quantum chemical calculation for lead optimization.

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Year:  2007        PMID： 17979803     DOI： 10.2174/138955707782110169

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  2 in total

1.  A high-content assay strategy for the identification and profiling of ABCG2 modulators in live cells.

Authors:  Christophe Antczak; Boyoung Wee; Constantin Radu; Bhavneet Bhinder; Eric C Holland; Hakim Djaballah
Journal:  Assay Drug Dev Technol       Date:  2013-08-30       Impact factor: 1.738

2.  Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro.

Authors:  Ran An; Yuichiro Hagiya; Ai Tamura; Shanshan Li; Hikaru Saito; Daisuke Tokushima; Toshihisa Ishikawa
Journal:  Pharm Res       Date:  2008-10-09       Impact factor: 4.580
  2 in total

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