Literature DB >> 17979145

Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads.

Arvind S Negi1, J K Kumar, Suaib Luqman, Karuna Shanker, M M Gupta, S P S Khanuja.   

Abstract

Medicinal plants have been traditionally used for treating liver diseases since centuries. Several leads from plant sources have been found as potential hepatoprotective agents with diverse chemical structures. Although, a big list of hepatoprotective phytomolecules was reported in the scientific literature, only a few were potent against various types of liver damages. Of which, silymarin, andrographolide, neoandrographolide, curcumin, picroside, kutkoside, phyllanthin, hypophyllanthin, and glycyrrhizin have largely attracted the scientific community. This review focuses discussion on the chemistry, biological activity, mode of action, toxicity, and future prospects of these leads.

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Year:  2008        PMID: 17979145     DOI: 10.1002/med.20115

Source DB:  PubMed          Journal:  Med Res Rev        ISSN: 0198-6325            Impact factor:   12.944


  34 in total

1.  Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo.

Authors:  Z J Zhai; H W Li; G W Liu; X H Qu; B Tian; W Yan; Z Lin; T T Tang; A Qin; K R Dai
Journal:  Br J Pharmacol       Date:  2014-02       Impact factor: 8.739

2.  Neuroprotective effect of picroside II in brain injury in mice.

Authors:  Yida Wang; Wei Fang; Liang Wu; Xueya Yao; Suzhen Wu; Jie Wang; Zhen Xu; Fubo Tian; Zhenzhou He; Bin Dong
Journal:  Am J Transl Res       Date:  2016-12-15       Impact factor: 4.060

3.  Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells.

Authors:  Sangeetha Sukumari-Ramesh; J Nicole Bentley; Melissa D Laird; Nagendra Singh; John R Vender; Krishnan M Dhandapani
Journal:  Int J Dev Neurosci       Date:  2011-06-17       Impact factor: 2.457

4.  Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity.

Authors:  S P Guan; W Tee; D S W Ng; T K Chan; H Y Peh; W E Ho; C Cheng; J C Mak; W S F Wong
Journal:  Br J Pharmacol       Date:  2013-04       Impact factor: 8.739

5.  A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP.

Authors:  Wan-Jung Lu; Jie-Jen Lee; Duen-Suey Chou; Thanasekaran Jayakumar; Tsorng-Han Fong; George Hsiao; Joen-Rong Sheu
Journal:  J Mol Med (Berl)       Date:  2011-08-06       Impact factor: 4.599

6.  Picroside II Attenuates CCI-Induced Neuropathic Pain in Rats by Inhibiting Spinal Reactive Astrocyte-Mediated Neuroinflammation Through the NF-κB Pathway.

Authors:  Xiaolian Nong; Yuyan Lan
Journal:  Neurochem Res       Date:  2018-04-18       Impact factor: 3.996

7.  Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells.

Authors:  Cheng Y Hsieh; Ming J Hsu; George Hsiao; Yi H Wang; Chi W Huang; Shiuan W Chen; Thanasekaran Jayakumar; Pei T Chiu; Yi H Chiu; Joen R Sheu
Journal:  J Biol Chem       Date:  2010-12-17       Impact factor: 5.157

8.  Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian).

Authors:  Wen-Wan Chao; Bi-Fong Lin
Journal:  Chin Med       Date:  2010-05-13       Impact factor: 5.455

9.  Andrographolide plays an important role in bleomycin-induced pulmonary fibrosis treatment.

Authors:  Jia-Ning Yin; Ya-Nan Li; Yang Gao; Shi-Bo Li; Jian-Dong Li
Journal:  Int J Clin Exp Med       Date:  2015-08-15

10.  Development of nanoformulation of picroliv isolated from Picrorrhiza kurroa.

Authors:  Anika Guliani; Avnesh Kumari; Dharmesh Kumar; Sudesh Kumar Yadav
Journal:  IET Nanobiotechnol       Date:  2016-06       Impact factor: 1.847

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