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Literature DB >> 1797892

Effect of surfactant replacement on Pneumocystis carinii pneumonia in rats.

E P Eijking¹, G J van Daal, R Tenbrinck, A Luijendijk, J F Sluiters, E Hannappel, B Lachmann.

Abstract

The effect of intratracheal surfactant instillation on pulmonary function in rats with Pneumocystis carinii pneumonia (PCP) was investigated. In those animals which developed PCP with severe respiratory failure after administration of cortisone acetate s.c. over 8-12 weeks, pulmonary function was improved by surfactant instillation. PaO2 values 30 min after surfactant instillation were significantly higher compared to pretreatment values and also compared to PaO2 values of rats 30 min after receiving saline (482.9 mmHg +/- 44.7, 170.7 mmHg +/- 39.3 and 67.2 mmHg +/- 17.4, respectively). Histological examination showed that alveoli of rats with PCP which received no exogenous surfactant are filled with foamy edema, whereas after exogenous surfactant alveoli are stabilized and well-aerated. These results indicate that exogenous surfactant may help patients with severe PCP to overcome an acute stage of respiratory distress.

Entities: Chemical Disease Species

Mesh：

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Year: 1991 PMID： 1797892 DOI： 10.1007/BF01690770

Source DB: PubMed Journal: Intensive Care Med ISSN： 0342-4642 Impact factor: 17.440

22 in total

1. Surfactant replacement therapy for severe neonatal respiratory distress syndrome: an international randomized clinical trial. Collaborative European Multicenter Study Group.

Authors:
Journal: Pediatrics Date: 1988-11 Impact factor: 7.124

2. A biophysical mechanism by which plasma proteins inhibit lung surfactant activity.

Authors: B A Holm; G Enhorning; R H Notter
Journal: Chem Phys Lipids Date: 1988-11 Impact factor: 3.329

3. Pneumocystis carinii pneumonia in the United States. Epidemiologic, diagnostic, and clinical features.

Authors: P D Walzer; D P Perl; D J Krogstad; P G Rawson; M G Schultz
Journal: Ann Intern Med Date: 1974-01 Impact factor: 25.391

4. Successful treatment with aerosolized pentamidine of Pneumocystis carinii pneumonia in rats.

Authors: R J Debs; W Blumenfeld; E N Brunette; R M Straubinger; A B Montgomery; E Lin; N Agabian; D Papahadjopoulos
Journal: Antimicrob Agents Chemother Date: 1987-01 Impact factor: 5.191

5. Functions of the alveolar lining.

Authors: J A Clements
Journal: Am Rev Respir Dis Date: 1977-06

6. Ten centre trial of artificial surfactant (artificial lung expanding compound) in very premature babies. Ten Centre Study Group.

Authors:
Journal: Br Med J (Clin Res Ed) Date: 1987-04-18

7. Alteration of surfactant function due to protein leakage: special interaction with fibrin monomer.

Authors: W Seeger; G Stöhr; H R Wolf; H Neuhof
Journal: J Appl Physiol (1985) Date: 1985-02

8. Mechanism of pulmonary alveolar injury in experimental Pneumocystis carinii pneumonia in the rat.

Authors: K Yoneda; P D Walzer
Journal: Br J Exp Pathol Date: 1981-08

9. Surfactant phospholipids and lavage phospholipase A2 in experimental Pneumocystis carinii pneumonia.

Authors: P M Sheehan; D C Stokes; Y Y Yeh; W T Hughes
Journal: Am Rev Respir Dis Date: 1986-09

10. Exogenous human surfactant for treatment of severe respiratory distress syndrome: a randomized prospective clinical trial.

Authors: M Hallman; T A Merritt; A L Jarvenpaa; B Boynton; F Mannino; L Gluck; T Moore; D Edwards
Journal: J Pediatr Date: 1985-06 Impact factor: 4.406

14 in total

Review 1. Surfactant replacement therapy.

Authors: M J Kresch; W H Lin; R S Thrall
Journal: Thorax Date: 1996-11 Impact factor: 9.139

2. Pulmonary surfactant as vehicle for intratracheally instilled tobramycin in mice infected with Klebsiella pneumoniae.

Authors: A van't Veen; J W Mouton; D Gommers; B Lachmann
Journal: Br J Pharmacol Date: 1996-11 Impact factor: 8.739

3. Pulmonary inflammation disrupts surfactant function during Pneumocystis carinii pneumonia.

Authors: T W Wright; R H Notter; Z Wang; A G Harmsen; F Gigliotti
Journal: Infect Immun Date: 2001-02 Impact factor: 3.441

Review 4. Surfactant therapy for acute lung injury and acute respiratory distress syndrome.

Authors: Krishnan Raghavendran; D Willson; R H Notter
Journal: Crit Care Clin Date: 2011-07 Impact factor: 3.598

5. Exogenous pulmonary surfactant as a drug delivering agent: influence of antibiotics on surfactant activity.

Authors: A van 't Veen; D Gommers; J W Mouton; J A Kluytmans; E J Krijt; B Lachmann
Journal: Br J Pharmacol Date: 1996-06 Impact factor: 8.739

6. Surfactant improves lung function and mitigates bacterial growth in immature ventilated rabbits with experimentally induced neonatal group B streptococcal pneumonia.

Authors: E Herting; B Sun; C Jarstrand; T Curstedt; B Robertson
Journal: Arch Dis Child Fetal Neonatal Ed Date: 1997-01 Impact factor: 5.747

7. In vivo evaluation of the inhibitory capacity of human plasma on exogenous surfactant function.

Authors: B Lachmann; E P Eijking; K L So; D Gommers
Journal: Intensive Care Med Date: 1994 Impact factor: 17.440

Review 8. Pharmacotherapy of acute lung injury and acute respiratory distress syndrome.

Authors: Krishnan Raghavendran; Gloria S Pryhuber; Patricia R Chess; Bruce A Davidson; Paul R Knight; Robert H Notter
Journal: Curr Med Chem Date: 2008 Impact factor: 4.530

9. Regulation of surfactant phosphatidylcholine secretion from alveolar type II cells during Pneumocystis carinii pneumonia in the rat.

Authors: W R Rice; F M Singleton; M J Linke; P D Walzer
Journal: J Clin Invest Date: 1993-12 Impact factor: 14.808

10. Influence of pulmonary surfactant on in vitro bactericidal activities of amoxicillin, ceftazidime, and tobramycin.

Authors: A van 't Veen; J W Mouton; D Gommers; J A Kluytmans; P Dekkers; B Lachmann
Journal: Antimicrob Agents Chemother Date: 1995-02 Impact factor: 5.191