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Literature DB >> 17978854

Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer.

Geert Berx¹, Eric Raspé, Gerhard Christofori, Jean Paul Thiery, Jonathan P Sleeman.

Abstract

EMT (epithelial-mesenchymal transition) is a morphogenetic process in which cells loose their epithelial characteristics and gain mesenchymal properties during embryogenesis. Similar processes regulated by similar pathways are recapitulated during tumour progression, endowing cells with invasive properties, thereby contributing to the formation of metastases. In this review, we outline key features of EMT and discuss the evidence for its involvement in the dissemination of tumours. Finally we review the recent literature concerning the mechanisms that regulate EMT in the tumour context, with a particular focus on breast cancer.

Entities: Disease

Mesh：

Year: 2007 PMID： 17978854 DOI： 10.1007/s10585-007-9114-6

Source DB: PubMed Journal: Clin Exp Metastasis ISSN： 0262-0898 Impact factor: 5.150

101 in total

1. Microarray analysis of gene expression during epithelial-mesenchymal transformation.

Authors: Damian LaGamba; Ali Nawshad; Elizabeth D Hay
Journal: Dev Dyn Date: 2005-09 Impact factor: 3.780

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Journal: Nature Date: 1997-02-27 Impact factor: 49.962

Review 3. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression.

Authors: Thomas Brabletz; Andreas Jung; Simone Spaderna; Falk Hlubek; Thomas Kirchner
Journal: Nat Rev Cancer Date: 2005-09 Impact factor: 60.716

Review 4. Molecular requirements for epithelial-mesenchymal transition during tumor progression.

Authors: Margit A Huber; Norbert Kraut; Hartmut Beug
Journal: Curr Opin Cell Biol Date: 2005-10 Impact factor: 8.382

5. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis.

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Journal: Cell Date: 1999-07-23 Impact factor: 41.582

6. ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells.

Authors: Thomas Waerner; Memetcan Alacakaptan; Ido Tamir; Rupert Oberauer; Annamaria Gal; Thomas Brabletz; Martin Schreiber; Martin Jechlinger; Hartmut Beug
Journal: Cancer Cell Date: 2006-09 Impact factor: 31.743

7. DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.

Authors: Andreas Eger; Kirsten Aigner; Stefan Sonderegger; Brigitta Dampier; Susanne Oehler; Martin Schreiber; Geert Berx; Amparo Cano; Hartmut Beug; Roland Foisner
Journal: Oncogene Date: 2005-03-31 Impact factor: 9.867

Review 8. Molecular mechanisms of cancer cell invasion and plasticity.

Authors: Katarina Wolf; Peter Friedl
Journal: Br J Dermatol Date: 2006-05 Impact factor: 9.302

9. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.

Authors: Marius Wernig; Alexander Meissner; Ruth Foreman; Tobias Brambrink; Manching Ku; Konrad Hochedlinger; Bradley E Bernstein; Rudolf Jaenisch
Journal: Nature Date: 2007-06-06 Impact factor: 49.962

10. The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity.

Authors: K Aigner; B Dampier; L Descovich; M Mikula; A Sultan; M Schreiber; W Mikulits; T Brabletz; D Strand; P Obrist; W Sommergruber; N Schweifer; A Wernitznig; H Beug; R Foisner; A Eger
Journal: Oncogene Date: 2007-05-07 Impact factor: 9.867

110 in total

Review 1. Involvement of members of the cadherin superfamily in cancer.

Authors: Geert Berx; Frans van Roy
Journal: Cold Spring Harb Perspect Biol Date: 2009-09-23 Impact factor: 10.005

Review 2. Evolutionary functional analysis and molecular regulation of the ZEB transcription factors.

Authors: Alexander Gheldof; Paco Hulpiau; Frans van Roy; Bram De Craene; Geert Berx
Journal: Cell Mol Life Sci Date: 2012-02-21 Impact factor: 9.261

3. ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells.

Authors: Justin M Drake; Garth Strohbehn; Thomas B Bair; Jessica G Moreland; Michael D Henry
Journal: Mol Biol Cell Date: 2009-02-18 Impact factor: 4.138

4. Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells.

Authors: Alessandra Pincini; Giusy Tornillo; Francesca Orso; Marianna Sciortino; Brigitte Bisaro; Maria Del Pilar Camacho Leal; Antonio Lembo; Maria Felice Brizzi; Emilia Turco; Cristiano De Pittà; Paolo Provero; Enzo Medico; Paola Defilippi; Daniela Taverna; Sara Cabodi
Journal: Cell Cycle Date: 2013-06-28 Impact factor: 4.534

5. Epithelial-mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth.

Authors: Takanori Tsuji; Soichiro Ibaragi; Kaori Shima; Miaofen G Hu; Miki Katsurano; Akira Sasaki; Guo-fu Hu
Journal: Cancer Res Date: 2008-12-15 Impact factor: 12.701

6. Suppression of triple-negative breast cancer metastasis by pan-DAC inhibitor panobinostat via inhibition of ZEB family of EMT master regulators.

Authors: Lyndsay V Rhodes; Chandra R Tate; H Chris Segar; Hope E Burks; Theresa B Phamduy; Van Hoang; Steven Elliott; Diari Gilliam; F Nell Pounder; Muralidharan Anbalagan; Douglas B Chrisey; Brian G Rowan; Matthew E Burow; Bridgette M Collins-Burow
Journal: Breast Cancer Res Treat Date: 2014-05-09 Impact factor: 4.872

10. Down-regualtion of miR-106b induces epithelial-mesenchymal transition but suppresses metastatic colonization by targeting Prrx1 in colorectal cancer.

Authors: Lin Zheng; Yuqin Zhang; Shuimiao Lin; Aimin Sun; Runze Chen; Yi Ding; Yanqing Ding
Journal: Int J Clin Exp Pathol Date: 2015-09-01