| Literature DB >> 17978501 |
Sang Jun Han1, Eun-Ah Bae, Hien Trung Trinh, Jung-Hwa Yang, Ui-Jung Youn, Ki-Hwan Bae, Dong-Hyun Kim.
Abstract
The antiallergic effects of magnolol and honokiol, isolated from the bark of Magnolia obovata (family Magnoliaceae), were investigated both in vitro and in vivo. Magnolol and honokiol potently inhibited passive cutaneous anaphylaxis reactions in mice induced by IgE-antigen complex as well as compound 48/80-induced scratching behaviors. These constituents exhibited not only potent inhibitory activity on the degranulation of RBL-2H3 cells induced by IgE-antigen complex, with IC(50) values of 45 and 55 muM, respectively, but also inhibited the protein expressions of IL-4 and TNF-alpha. Based on these findings, magnolol and honokiol may improve IgE-induced allergic diseases.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17978501 DOI： 10.1248/bpb.30.2201
Source DB: PubMed Journal: Biol Pharm Bull ISSN： 0918-6158 Impact factor: 2.233