Literature DB >> 17978478

Maslinic acid reduces blood glucose in KK-Ay mice.

Jun Liu1, Hongbin Sun, Weigang Duan, Dongyan Mu, Luyong Zhang.   

Abstract

In the present study, we have examined the hypoglycemic effect of maslinic acid (MA) in KK-A(y) mice, an animal model of genetic type-2 diabetes. MA (10 mg/kg body wt) reduced the blood glucose levels in KK-A(y) mice at 4 h after a single oral dose. KK-A(y) mice receiving MA at daily dosages of 10 mg/kg and 30 mg/kg for 2 weeks showed a significant reduction in the blood glucose levels. Furthermore, the results also showed that MA might modulate glucose metabolism partially through reducing insulin resistance in KK-A(y) mice. Taken together, MA may hold great promise as a natural therapeutic agent for treatment of type 2 diabetes.

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Year:  2007        PMID： 17978478     DOI： 10.1248/bpb.30.2075

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  20 in total

1.  Maslinic acid induces apoptosis in salivary gland adenoid cystic carcinoma cells by Ca2+-evoked p38 signaling pathway.

Authors:  Dong-Mei Wu; Dan Zhao; De-Zhi Li; Dong-Yang Xu; Wen-Feng Chu; Xiao-Feng Wang
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2011-01-29       Impact factor: 3.000

2.  Gastroprotective activity of the methanol extract from peels of Plinia edulis (Vell.) Sobral fruits and its isolated triterpenes: maslinic and ursolic acids.

Authors:  Roseane Leandra da Rosa; Luciane Ângela Nottar Nesello; Luisa Nathalia Bolda Mariano; Lincon Bordignon Somensi; Adriana Campos; Ana Myrelle Pinheiro; Sabrina Costa; Marjana Rial; Mariana Tozzo; Valdir Cechinel-Filho; Sérgio Faloni de Andrade; Luísa Mota Da Silva
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2017-12-05       Impact factor: 3.000

3.  Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor alpha by inhibiting NF-kappaB signaling pathway.

Authors:  Chenghai Li; Zhengfeng Yang; Chunyan Zhai; Wenwei Qiu; Dali Li; Zhengfang Yi; Lei Wang; Jie Tang; Min Qian; Jian Luo; Mingyao Liu
Journal:  Mol Cancer       Date:  2010-04-06       Impact factor: 27.401

4.  Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations.

Authors:  Arie Gruzman; Gali Babai; Shlomo Sasson
Journal:  Rev Diabet Stud       Date:  2009-05-10

5.  Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages.

Authors:  Carlos Moneriz; Patricia Marín-García; Andrés García-Granados; José M Bautista; Amalia Diez; Antonio Puyet
Journal:  Malar J       Date:  2011-04-10       Impact factor: 2.979

Review 6.  Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes.

Authors:  Jose M Castellano; Angeles Guinda; Teresa Delgado; Mirela Rada; Jose A Cayuela
Journal:  Diabetes       Date:  2013-06       Impact factor: 9.461

7.  Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia.

Authors:  Kuo Xu; Penglong Wang; Bin Yuan; Yatao Cheng; Qiang Li; Haimin Lei
Journal:  Chem Cent J       Date:  2013-05-04       Impact factor: 4.215

8.  Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming.

Authors:  Susana Sánchez-Tena; Fernando J Reyes-Zurita; Santiago Díaz-Moralli; Maria Pilar Vinardell; Michelle Reed; Francisco García-García; Joaquín Dopazo; José A Lupiáñez; Ulrich Günther; Marta Cascante
Journal:  PLoS One       Date:  2013-03-18       Impact factor: 3.240

9.  Maslinic Acid, a Triterpene from Olive, Affects the Antioxidant and Mitochondrial Status of B16F10 Melanoma Cells Grown under Stressful Conditions.

Authors:  Khalida Mokhtari; Eva E Rufino-Palomares; Amalia Pérez-Jiménez; Fernando J Reyes-Zurita; Celeny Figuera; Leticia García-Salguero; Pedro P Medina; Juan Peragón; José A Lupiáñez
Journal:  Evid Based Complement Alternat Med       Date:  2015-07-07       Impact factor: 2.629

Review 10.  The role of triterpenes in the management of diabetes mellitus and its complications.

Authors:  J Nazaruk; M Borzym-Kluczyk
Journal:  Phytochem Rev       Date:  2014-06-24       Impact factor: 5.374
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