Literature DB >> 1797846

Direct determination of codeine, norcodeine, morphine and normorphine with their corresponding O-glucuronide conjugates by high-performance liquid chromatography with electrochemical detection.

C P Verwey-van Wissen1, P M Koopman-Kimenai, T B Vree.   

Abstract

A high-performance liquid chromatographic method has been developed for the detection, separation and measurement of codeine and its metabolites norcodeine, morphine and normorphine, with their glucuronide conjugates. The glucuronidase Escherichia coli type VIIA hydrolyses codeine-6-glucuronide completely and is used for the construction of the calibration curves of codeine-6-glucuronide. Enzymic hydrolysis of codeine-6-glucuronide depends on the specific activity of the glucuronidase applied. Examples are shown of a volunteer who is able to form morphine from codeine and one who is unable to do so.

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Year:  1991        PMID： 1797846     DOI： 10.1016/0378-4347(91)80534-j

Source DB:  PubMed          Journal:  J Chromatogr


  6 in total

1.  Morphine metabolite pharmacokinetics during venoarterial extra corporeal membrane oxygenation in neonates.

Authors:  Jeroen W B Peters; Brian J Anderson; Sinno H P Simons; Donald R A Uges; Dick Tibboel
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

2.  Direct measurement of probenecid and its glucuronide conjugate by means of high pressure liquid chromatography in plasma and urine of humans.

Authors:  T B Vree; E W Beneken Kolmer
Journal:  Pharm Weekbl Sci       Date:  1992-06-19

3.  Morphine pharmacokinetics during venoarterial extracorporeal membrane oxygenation in neonates.

Authors:  Jeroen W B Peters; Brian J Anderson; Sinno H P Simons; Donald R A Uges; Dick Tibboel
Journal:  Intensive Care Med       Date:  2005-01-28       Impact factor: 17.440

4.  Postoperative pain in the neonate: age-related differences in morphine requirements and metabolism.

Authors:  Nancy J Bouwmeester; Wim C J Hop; Monique van Dijk; K J S Anand; John N van den Anker; Dick Tibboel
Journal:  Intensive Care Med       Date:  2003-07-25       Impact factor: 17.440

5.  Capacity-limited renal glucuronidation of probenecid by humans. A pilot Vmax-finding study.

Authors:  T B Vree; E W Van Ewijk-Beneken Kolmer; E W Wuis; Y A Hekster
Journal:  Pharm Weekbl Sci       Date:  1992-10-16

6.  Morphine pharmacokinetics and pharmacodynamics in preterm and term neonates: secondary results from the NEOPAIN trial.

Authors:  K J S Anand; B J Anderson; N H G Holford; R W Hall; T Young; B Shephard; N S Desai; B A Barton
Journal:  Br J Anaesth       Date:  2008-08-23       Impact factor: 9.166
  6 in total

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