OBJECTIVE: The purpose of this study was to introduce a novel meal detection algorithm (MDA) to be used as part of an artificial beta-cell that uses a continuous glucose monitor (CGM). RESEARCH DESIGN AND METHODS: We developed our MDA on a dataset of 26 meal events using records from 19 children aged 1-6 years who used the MiniMed CGMS Gold. We then applied this algorithm to CGM records from a DirecNet pilot study of the FreeStyle Navigator continuous glucose sensor. During a research center admission, breakfast insulin was withheld for 1 h, and discrete glucose levels were obtained every 10 min after the meal. RESULTS: Based on the Navigator readings, the MDA detected a meal at a mean time of 30 min from the onset of eating, at which time the mean serum glucose was 21 mg/dl above baseline (range 2-36 mg/dl), and >90% of meals were detected before the glucose had risen 40 mg/dl from baseline. CONCLUSIONS: The MDA will enable automated insulin dosing in response to meals, facilitating the development of an artificial pancreas.
OBJECTIVE: The purpose of this study was to introduce a novel meal detection algorithm (MDA) to be used as part of an artificial beta-cell that uses a continuous glucose monitor (CGM). RESEARCH DESIGN AND METHODS: We developed our MDA on a dataset of 26 meal events using records from 19 children aged 1-6 years who used the MiniMed CGMS Gold. We then applied this algorithm to CGM records from a DirecNet pilot study of the FreeStyle Navigator continuous glucose sensor. During a research center admission, breakfast insulin was withheld for 1 h, and discrete glucose levels were obtained every 10 min after the meal. RESULTS: Based on the Navigator readings, the MDA detected a meal at a mean time of 30 min from the onset of eating, at which time the mean serum glucose was 21 mg/dl above baseline (range 2-36 mg/dl), and >90% of meals were detected before the glucose had risen 40 mg/dl from baseline. CONCLUSIONS: The MDA will enable automated insulin dosing in response to meals, facilitating the development of an artificial pancreas.
Authors: Youqing Wang; Matthew W Percival; Eyal Dassau; Howard C Zisser; Lois Jovanovic; Francis J Doyle Journal: J Diabetes Sci Technol Date: 2009-09-01
Authors: Daniela Bruttomesso; Anne Farret; Silvana Costa; Maria Cristina Marescotti; Monica Vettore; Angelo Avogaro; Antonio Tiengo; Chiara Dalla Man; Jerome Place; Andrea Facchinetti; Stefania Guerra; Lalo Magni; Giuseppe De Nicolao; Claudio Cobelli; Eric Renard; Alberto Maran Journal: J Diabetes Sci Technol Date: 2009-09-01
Authors: Eyal Dassau; Fraser Cameron; Hyunjin Lee; B Wayne Bequette; Howard Zisser; Lois Jovanovic; H Peter Chase; Darrell M Wilson; Bruce A Buckingham; Francis J Doyle Journal: Diabetes Care Date: 2010-06 Impact factor: 17.152