| Literature DB >> 17977532 |
Agasa Miyazono1, Atsushi Yamada, Naoko Morimura, Masamichi Takami, Dai Suzuki, Makoto Kobayashi, Ken-Ichi Tezuka, Matsuo Yamamoto, Ryutaro Kamijo.
Abstract
POEM, also called nephronectin, is an extracellular matrix protein that is considered to play a critical role as an adhesion molecule in the development and functioning of various tissues, such as kidneys and bones. In the present study, we examined the molecular mechanism of POEM gene expression, and found that transforming growth factor-beta (TGF-beta) strongly inhibited POEM expression in the mouse osteoblastic cell line, MC3T3-E1. TGF-beta-induced decrease of POEM expression occurred in both time- and dose-dependent manners through the activation of TGF-beta receptor I and extracellular signal-regulated kinase/c-Jun N-terminal kinase pathways.Entities:
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Year: 2007 PMID： 17977532 DOI： 10.1016/j.febslet.2007.10.021
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124