Literature DB >> 17976876

Production of recombinant HIV-1/HBV virus-like particles in Nicotiana tabacum and Arabidopsis thaliana plants for a bivalent plant-based vaccine.

Raffaella Greco1, Marie Michel, Denise Guetard, Minerva Cervantes-Gonzalez, Nilla Pelucchi, Simon Wain-Hobson, Francesco Sala, Monica Sala.   

Abstract

Human immunodeficiency virus (HIV-1) and hepatitis B virus (HBV) spread via similar transmission pathways, and infection by HBV occurs in up to 32% of HIV-1 cases. Here, we describe the successful expression of novel recombinant HIV-1/HBV virus-like particles (VLPs) in Nicotiana tabacum and Arabidopsis thaliana. The production levels and quality of the recombinant VLPs were comparable in the two plants, showing that parameters intrinsic to the recombinant proteins determined their assembly into VLPs. These heterologous VLPs can be used in a bivalent anti-HIV-1/-HBV vaccine, administrated via ingestion of transgenic plants.

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Year:  2007        PMID： 17976876     DOI： 10.1016/j.vaccine.2007.09.061

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  22 in total

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Review 2.  Plant-derived virus-like particles as vaccines.

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4.  Viruslike Particles Encapsidating Respiratory Syncytial Virus M and M2 Proteins Induce Robust T Cell Responses.

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Journal:  ACS Biomater Sci Eng       Date:  2016-11-03

Review 5.  Current status and perspectives of plant-based candidate vaccines against the human immunodeficiency virus (HIV).

Authors:  Sergio Rosales-Mendoza; Néstor Rubio-Infante; Dania O Govea-Alonso; Leticia Moreno-Fierros
Journal:  Plant Cell Rep       Date:  2011-12-13       Impact factor: 4.570

Review 6.  Progress towards a needle-free hepatitis B vaccine.

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Journal:  Pharm Res       Date:  2010-11-19       Impact factor: 4.200

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Authors:  Shailja Tiwari; Suresh P Vyas
Journal:  Curr Infect Dis Rep       Date:  2011-02       Impact factor: 3.725

Review 8.  Current status of viral expression systems in plants and perspectives for oral vaccines development.

Authors:  Jorge A Salazar-González; Bernardo Bañuelos-Hernández; Sergio Rosales-Mendoza
Journal:  Plant Mol Biol       Date:  2015-01-06       Impact factor: 4.335

9.  High-level expression of the HIV-1 Pr55gag polyprotein in transgenic tobacco chloroplasts.

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Journal:  Planta       Date:  2009-02-21       Impact factor: 4.540

Review 10.  Plant-based solutions for veterinary immunotherapeutics and prophylactics.

Authors:  Igor Kolotilin; Ed Topp; Eric Cox; Bert Devriendt; Udo Conrad; Jussi Joensuu; Eva Stöger; Heribert Warzecha; Tim McAllister; Andrew Potter; Michael D McLean; J Christopher Hall; Rima Menassa
Journal:  Vet Res       Date:  2014-12-31       Impact factor: 3.683
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