Literature DB >> 17976866

[Should we care about pregabalin for elderly patients with a history of cardiac dysrhythmia?].

M-A Laville1, B de la Gastine, B Husson, R Le Boisselier, B Mosquet, A Coquerel.   

Abstract

Pregabalin is similar in structure to gamma-aminobutyric acid. It is used for neuropathic pain, generalized anxiety disorders and as an adjunct therapy for partial seizures. Tachycardia is a rare side-effect. A 92-year-old patient with a history of paroxystic fibrillation was hospitalised for zoster. She developed a sinusal tachycardia followed by atrial fibrillation and congestive heart failure 15 h after a first dose of pregabalin. The imputation was considered as plausible. Even though the mechanism remains unclear, pregabalin might induce tachycardia in predisposed old patients.

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Year:  2007        PMID: 17976866     DOI: 10.1016/j.revmed.2007.07.009

Source DB:  PubMed          Journal:  Rev Med Interne        ISSN: 0248-8663            Impact factor:   0.728


  4 in total

1.  New treatment option for partial-onset seizures: efficacy and safety of lacosamide.

Authors:  Steve S Chung
Journal:  Ther Adv Neurol Disord       Date:  2010-03       Impact factor: 6.570

Review 2.  Pharmacotherapy of epilepsy: newly approved and developmental agents.

Authors:  Linda J Stephen; Martin J Brodie
Journal:  CNS Drugs       Date:  2011-02       Impact factor: 5.749

3.  Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database.

Authors:  Leticia Ortiz de Landaluce; Pere Carbonell; Carmen Asensio; Núria Escoda; Pilar López; Joan-Ramon Laporte
Journal:  Drug Saf       Date:  2018-12       Impact factor: 5.606

4.  Pregabalin in neuropathic pain: evidences and possible mechanisms.

Authors:  Vivek Verma; Nirmal Singh; Amteshwar Singh Jaggi
Journal:  Curr Neuropharmacol       Date:  2014-01       Impact factor: 7.363

  4 in total

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