OBJECTIVE: To assess visual function 15 years after acute unilateral optic neuritis. DESIGN: Longitudinal follow-up of a randomized clinical trial. PARTICIPANTS: Two hundred ninety-four patients who were randomized in the Optic Neuritis Treatment Trial between 1988 and 1991 and underwent examination in 2006. TESTING: A neuro-ophthalmic examination included measurements of visual acuity, contrast sensitivity, and visual field. Quality of life was assessed with the National Eye Institute Visual Function Questionnaire and Neuro-ophthalmic Supplement. MAIN OUTCOME MEASURES: Abnormal vision and health-related quality-of-life scores. RESULTS: Seventy-two percent of the eyes affected with optic neuritis at study entry had visual acuity of > or = 20/20 and 66% of patients had > or = 20/20 acuity in both eyes. On average, visual function was slightly worse among patients with multiple sclerosis (MS) than among with those without MS. As expected, quality-of-life scores were lower when acuity was reduced and when neurologic disability from MS was present. CONCLUSIONS: Long-term visual outcome is favorable for the majority of patients who experience optic neuritis even when MS is present.
OBJECTIVE: To assess visual function 15 years after acute unilateral optic neuritis. DESIGN: Longitudinal follow-up of a randomized clinical trial. PARTICIPANTS: Two hundred ninety-four patients who were randomized in the Optic Neuritis Treatment Trial between 1988 and 1991 and underwent examination in 2006. TESTING: A neuro-ophthalmic examination included measurements of visual acuity, contrast sensitivity, and visual field. Quality of life was assessed with the National Eye Institute Visual Function Questionnaire and Neuro-ophthalmic Supplement. MAIN OUTCOME MEASURES: Abnormal vision and health-related quality-of-life scores. RESULTS: Seventy-two percent of the eyes affected with optic neuritis at study entry had visual acuity of > or = 20/20 and 66% of patients had > or = 20/20 acuity in both eyes. On average, visual function was slightly worse among patients with multiple sclerosis (MS) than among with those without MS. As expected, quality-of-life scores were lower when acuity was reduced and when neurologic disability from MS was present. CONCLUSIONS: Long-term visual outcome is favorable for the majority of patients who experience optic neuritis even when MS is present.
Authors: Robert L Harrigan; Andrew J Plassard; Frederick W Bryan; Gabriela Caires; Louise A Mawn; Lindsey M Dethrage; Siddharama Pawate; Robert L Galloway; Seth A Smith; Bennett A Landman Journal: Magn Reson Med Date: 2015-03-07 Impact factor: 4.668
Authors: Eric D Gaier; Katherine Boudreault; Joseph F Rizzo; Julie Falardeau; Dean M Cestari Journal: Curr Neurol Neurosci Rep Date: 2015-12 Impact factor: 5.081