AIM: A positive effect of liver transplantation on health-related quality of life (HRQOL) has been well documented in previous studies using generic instruments. Our aim was to re-evaluate different aspects of HRQOL before and after liver transplantation with a relatively new questionnaire the 'liver disease quality of life' (LDQOL). METHODS: The LDQOL and the Short Form 36 (SF-36) questionnaires were applied to ambulatory patients, either in the transplant list (n=65) or after 6 months to 5 years of liver transplant (n=61). The aetiology of cirrhosis, comorbidities, model for end-stage liver disease (MELD) Child-Pugh scores and recurrence of liver disease after liver transplantation were analysed using the Mann-Whitney and Kruskall-Wallis tests. RESULTS: In patients awaiting liver transplantation, MELD scores > or =15 and Child-Pugh class C showed statistically significant worse HRQOL, using both the SF-36 and the LDQOL questionnaires. HRQOL in pretransplant patients was found to be significantly worse in those with cirrhosis owing to hepatitis C (n=30) when compared with other aetiologies (n=35) in 2/7 domains of the SF-36 and in 7/12 domains of the LDQOL. Significant deterioration of HRQOL after recurrence of hepatitis C post-transplant was detected with the LDQOL questionnaire although not demonstrated with the SF-36. The statistically significant differences were in the LDQOL domains: symptoms of liver disease, concentration, memory and health distress. CONCLUSIONS: The LDQOL, a specific instrument for measuring HRQOL, has shown a greater accuracy in relation to liver symptoms and could demonstrate, with better reliability, impairments before and after liver transplantation.
AIM: A positive effect of liver transplantation on health-related quality of life (HRQOL) has been well documented in previous studies using generic instruments. Our aim was to re-evaluate different aspects of HRQOL before and after liver transplantation with a relatively new questionnaire the 'liver disease quality of life' (LDQOL). METHODS: The LDQOL and the Short Form 36 (SF-36) questionnaires were applied to ambulatory patients, either in the transplant list (n=65) or after 6 months to 5 years of liver transplant (n=61). The aetiology of cirrhosis, comorbidities, model for end-stage liver disease (MELD) Child-Pugh scores and recurrence of liver disease after liver transplantation were analysed using the Mann-Whitney and Kruskall-Wallis tests. RESULTS: In patients awaiting liver transplantation, MELD scores > or =15 and Child-Pugh class C showed statistically significant worse HRQOL, using both the SF-36 and the LDQOL questionnaires. HRQOL in pretransplant patients was found to be significantly worse in those with cirrhosis owing to hepatitis C (n=30) when compared with other aetiologies (n=35) in 2/7 domains of the SF-36 and in 7/12 domains of the LDQOL. Significant deterioration of HRQOL after recurrence of hepatitis C post-transplant was detected with the LDQOL questionnaire although not demonstrated with the SF-36. The statistically significant differences were in the LDQOL domains: symptoms of liver disease, concentration, memory and health distress. CONCLUSIONS: The LDQOL, a specific instrument for measuring HRQOL, has shown a greater accuracy in relation to liver symptoms and could demonstrate, with better reliability, impairments before and after liver transplantation.
Authors: Zeeshan Butt; Neehar D Parikh; Anton I Skaro; Daniela Ladner; David Cella Journal: Curr Opin Organ Transplant Date: 2012-06 Impact factor: 2.640
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Authors: María Teresa García-Rodríguez; María Del Carmen Piñón-Villar; Beatriz López-Calviño; Alejandra Otero-Ferreiro; Francisco Suárez-López; Manuel Gómez-Gutiérrez; Salvador Pita-Fernández Journal: BMC Gastroenterol Date: 2015-01-22 Impact factor: 3.067
Authors: Daniela P Ladner; Mary Amanda Dew; Sarah Forney; Brenda W Gillespie; Robert S Brown; Robert M Merion; Chris E Freise; Paul H Hayashi; Johnny C Hong; April Ashworth; Carl L Berg; James R Burton; Abraham Shaked; Zeeshan Butt Journal: J Hepatol Date: 2014-09-06 Impact factor: 30.083
Authors: Francisco Augusto Porto Ferreira; Cesar de Almeida-Neto; Maria Cristina Dias Teixeira; Edna Strauss Journal: Rev Bras Hematol Hemoter Date: 2015-09-13